SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED PHENYL ACYL BROMIDE DERIVATIVES AND ITS BIOLOGICAL EVALUATION

Tarannum Fatima , Sara Fatima , Gul Afshan , Fatima Mehwish , Kulsum Fatima

anthelminthic activity, antibacterial activity, nitroscanate, thiazole

A series of N – [4 – (4-nitrophenoxy) phenyl] – 4 – (substituted) – 1,3 – thiazol – 2 – amines was synthesized. Structural elucidation was accomplished by, 13C NMR, IR, and elemental analyses of synthesized compounds. The title compounds were derived from 4-(4-nitrophenoxy) phenyl thiourea, which is the key intermediate in the synthesis of nitroscanate, an anthelminthic drug. This study reports on the synthesis, characterization, and evaluation of N-[4-(4-nitrophenoxy) phenyl]-4-(substituted)-1,3-thiazol-2-amines for their potential anthelminthic activity. The compounds were synthesized via cyclization of 4-(4-nitrophenoxy) aniline with various substituted α-haloketones. The structures of the synthesized compounds were confirmed using Nuclear Magnetic Resonance , IR spectroscopy, and Mass Spectrometry. The anthelminthic activity was evaluated against model helminth parasites using standard bioassays, which revealed significant activity for several derivatives. Further optimization and detailed biological studies are warranted to fully explore their therapeutic potential

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"SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED PHENYL ACYL BROMIDE DERIVATIVES AND ITS BIOLOGICAL EVALUATION", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 7, page no.95 - 108, July-2024, Available :https://ijsdr.org/papers/IJSDR2407011.pdf

Volume 9 Issue 7, July-2024

Pages : 95 - 108

Paper Reg. ID: IJSDR_211934

Published Paper Id: IJSDR2407011

Downloads: 000347454

Research Area: Pharmacy

Country: Hyderabad, Telangana, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2407011

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2407011

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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