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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: November 2024

Volume 9 | Issue 11

Impact factor: 8.15

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Paper Title: SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED PHENYL ACYL BROMIDE DERIVATIVES AND ITS BIOLOGICAL EVALUATION
Authors Name: Tarannum Fatima , Sara Fatima , Gul Afshan , Fatima Mehwish , Kulsum Fatima
Unique Id: IJSDR2407011
Published In: Volume 9 Issue 7, July-2024
Abstract: A series of N – [4 – (4-nitrophenoxy) phenyl] – 4 – (substituted) – 1,3 – thiazol – 2 – amines was synthesized. Structural elucidation was accomplished by, 13C NMR, IR, and elemental analyses of synthesized compounds. The title compounds were derived from 4-(4-nitrophenoxy) phenyl thiourea, which is the key intermediate in the synthesis of nitroscanate, an anthelminthic drug. This study reports on the synthesis, characterization, and evaluation of N-[4-(4-nitrophenoxy) phenyl]-4-(substituted)-1,3-thiazol-2-amines for their potential anthelminthic activity. The compounds were synthesized via cyclization of 4-(4-nitrophenoxy) aniline with various substituted α-haloketones. The structures of the synthesized compounds were confirmed using Nuclear Magnetic Resonance , IR spectroscopy, and Mass Spectrometry. The anthelminthic activity was evaluated against model helminth parasites using standard bioassays, which revealed significant activity for several derivatives. Further optimization and detailed biological studies are warranted to fully explore their therapeutic potential
Keywords: anthelminthic activity, antibacterial activity, nitroscanate, thiazole
Cite Article: "SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED PHENYL ACYL BROMIDE DERIVATIVES AND ITS BIOLOGICAL EVALUATION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 7, page no.95 - 108, July-2024, Available :http://www.ijsdr.org/papers/IJSDR2407011.pdf
Downloads: 000347016
Publication Details: Published Paper ID: IJSDR2407011
Registration ID:211934
Published In: Volume 9 Issue 7, July-2024
DOI (Digital Object Identifier):
Page No: 95 - 108
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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