Formulation and Evaluation of Effervescent Tablet of Analgesic and Antipyretic
Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). Rapid GI transit can prevent complete drug release in the absorption zone and reduce the efficacy of the administered dose. Effervescent tablets are becoming increasingly popular in a variety of sectors including supplements and pharmaceutical use due to the ease in which they can be consumed. Effervescent tablets are designed to break in contact with liquid such as water or juice, often causing the tablet to dissolve into a solution. These buoyant delivery systems utilize matrices prepared with swell able polymers such as Methocel or poly saccharides, e.g., chitosan, and effervescent components, e.g., sodium bicarbonate and citric or tartaric acid or matrices containing chambers of liquid that gasify at body temperature. Flotation of a drug delivery system in the stomach can be achieved by incorporating a floating chamber filled with vacuum, air or an inert gas. Gas can be introduced into the floating chamber by the volatilization of an organic solvent (e.g. Ether or cyclopentane) or by the CO2 produced as a result of an effervescent reaction between organic acids and carbonate–bicarbonate salts. The matrices are fabricated so that upon arrival in the stomach, carbon dioxide is liberated by the acidity of the gastric contents and is entrapped in the jellified hydrocolloid. This produces an upward motion of the dosage form and maintains its buoyancy. A decrease in specific gravity causes the dosage form to float on the chyme. Recently a multiple-unit type of floating pill, which generates carbon dioxide gas, has been developed. The system consisted of sustained- release pills as seeds surrounded by double layers. The inner layer was an effervescent layer containing both sodium bicarbonate and tartaric acid. The outer layer was a swellable membrane layer containing mainly polyvinyl acetate and purified shellac. Moreover, the effervescent layer was divided into two sub layers to avoid direct contact between sodium bicarbonate and tartaric acid. Sodium bicarbonate was contained in the inner sublayer and tartaric acid was in the outer layer. When the system was immersed in a buffer solution at 37°C, it sank at once in the solution and formed swollen pills, like balloons, with a density much lower than 1 g/ ml. The reaction was due to carbon dioxide generated Patel et al by neutralization in the inner effervescent layers with the
diffusion of water through the outer swellable membrane layers.
"Formulation and Evaluation of Effervescent Tablet of Analgesic and Antipyretic", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.b1-b101, September-2025, Available :https://ijsdr.org/papers/IJSDRTH01013.pdf
Volume 10
Issue 9,
September-2025
Pages : b1-b101
Paper Reg. ID: IJSDR_304758
Published Paper Id: IJSDRTH01013
Downloads: 000223
Research Area: Life Sciences All
Country: Pune, Maharashtra , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
