Study of evaluation of tranexamic acid in reducing blood loss and transfusions in Total Knee Replacement surgeries

Dhanraj Game , Ashish Somani , Kailash Ghorpade , Nitin Ghule , Saurabh Dahiphale

Tranexamic acid; Total knee replacement; Blood loss; Blood transfusion

Background: Total knee replacement (TKR) is associated with significant perioperative blood loss, often necessitating blood transfusion. Tranexamic acid (TXA) is an antifibrinolytic agent used to reduce blood loss. Aim: To evaluate the effectiveness and safety of tranexamic acid in reducing perioperative blood loss and transfusion requirements in patients undergoing TKR. Materials and Methods: A prospective observational study including 90 patients undergoing unilateral primary TKR. Intravenous TXA was administered perioperatively. Hematological parameters, estimated blood loss, transfusion requirements, and complications were assessed. Results: Mean estimated blood loss was 528 ± 148 mL. Blood transfusion was required in 20% of patients. No thromboembolic events were observed. Conclusion: Tranexamic acid effectively reduces perioperative blood loss and transfusion requirements without increasing complications.

Published Paper   E-Certificate

"Study of evaluation of tranexamic acid in reducing blood loss and transfusions in Total Knee Replacement surgeries", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.11, Issue 1, page no.b205-b210, January-2026, Available :https://ijsdr.org/papers/IJSDR2601125.pdf

Volume 11 Issue 1, January-2026

Pages : b205-b210

Paper Reg. ID: IJSDR_307013

Published Paper Id: IJSDR2601125

Downloads: 000190

Research Area: Health Science All

Country: Parbhani, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2601125

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2601125

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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