Phytochemical Screening And Evaluation of Antidiarrheal Activity of Eichhornia Crassipes in Experimental Animals
Huma Parveen
, Dr. Pushpendra Kannojia
Eichhornia Crassipes, Castor Oil, Intestinal Transit, Loperamide
Background and Objectives: Eichhornia crassipes, belonging to the family Pontederiaceae, is used in Indian traditional medicine to treat diarrhea. This study aims to investigate the anti-diarrheal activity of the methanolic extract of leaves of Eichhornia crassipes (Water hyacinth) by castor oil-induced diarrhea and charcoal meal tests in wistar albino rats.
Methods: All animals were divided into five groups of six animals each. In castor oil-induced diarrhea, castor oil (0.4ml/animal) was used as an inducer, and loperamide (3mg/kg) was used as standard drug. In charcoal induced diarrhea, loperamide (3mg/kg) was used as standard drug. Methanolic extract of Eichhornia crassipes was administered to rats at 100, 200 and 400mg/kg respectively. These rats were monitored for 6 hour and the first defecation time was noted. Charcoal meal test was performed on the rats.
Result: The extract produced a significant decrease in the severity of diarrhea. The activity was found to be dose-dependant. Its effect when evaluated on intestinal transit produced a decrease in intestinal transit (59.97%).The results revealed that the methanolic extract significantly reduced diarrhea in rats with reduction in weight of stools.
Conclusion: Methanolic extract of Eichhornia crassipes alleviates diarrhea at higher dose 400mg/kg. Tannins, flavonoids and terpenoids may be responsible for antidiarrheal effect.
"Phytochemical Screening And Evaluation of Antidiarrheal Activity of Eichhornia Crassipes in Experimental Animals", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.11, Issue 1, page no.b17-b23, January-2026, Available :https://ijsdr.org/papers/IJSDR2601102.pdf
Volume 11
Issue 1,
January-2026
Pages : b17-b23
Paper Reg. ID: IJSDR_306855
Published Paper Id: IJSDR2601102
Downloads: 000213
Research Area: Pharmacy All
Country: Bareilly, Uttar Pradesh, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
