Hyperglycemia-Induced Alterations in Colonic Motility and Secretion: Roles of 5-Hydroxytryptamine Signaling and Translational Implications

Paulitha Pasala Rph

Diabetes mellitus; Colonic motility; Epithelial secretion; Serotonin; Hyperglycemia

Diabetes mellitus is frequently associated with gastrointestinal dysfunction, traditionally linked to gastric dysmotility. Recent evidence demonstrates that chronic hyperglycemia also disrupts colonic motility and epithelial secretion, contributing to constipation, diarrhea, and fecal incontinence. Experimental studies using streptozotocin-induced hyperglycemia reveal impaired coordination between smooth muscle contractility and epithelial ion transport within the colon. These processes are closely regulated by enteric serotonergic signaling. 5-Hydroxytryptamine (5-HT) plays a central role in enteric neuron activation, smooth muscle excitation, and epithelial secretory responses. Sustained hyperglycemia alters 5-HT receptor expression, serotonin transporter function, and enteric neuronal integrity. This review synthesizes current scientific advancements and discusses translational implications for targeted therapeutic development.

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"Hyperglycemia-Induced Alterations in Colonic Motility and Secretion: Roles of 5-Hydroxytryptamine Signaling and Translational Implications", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.11, Issue 1, page no.a517-a518, January-2026, Available :https://ijsdr.org/papers/IJSDR2601053.pdf

Volume 11 Issue 1, January-2026

Pages : a517-a518

Paper Reg. ID: IJSDR_306851

Published Paper Id: IJSDR2601053

Downloads: 000309

Research Area: Science and Technology

Country: -, -, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2601053

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2601053

DOI: https://doi.org/10.56975/ijsdr.v11i1.306851

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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