Applications of Thermoresponsive Hydrogels in Tissue Engineering: A Comprehensive Review

Dr. Rashmi Kumari

Thermoresponsive Hydrogels, Scaffold, Cartilage, Encapsulation, Tissue Engineering.

Thermoresponsive hydrogels have gained considerable attention in tissue engineering due to their unique sol–gel transition behaviour near physiological temperatures, enabling minimally invasive administration, in situ scaffold formation, controlled release of therapeutic agents and enhanced integration with host tissues. Their ability to mimic the extracellular matrix (ECM) and encapsulate cells, growth factors or bioactive molecules makes them promising candidates for regeneration of structurally diverse tissues including cartilage, bone, neural, cardiac, skin, corneal and vascular systems (Hoffman, 1995; Li & Mooney, 2016). Recent advances in polymer chemistry, nanotechnology and bio-fabrication, particularly 3D and 4D bioprinting have significantly expanded the versatility and functionality of thermoresponsive hydrogels (Ramanathan, 2024; Wang et al., 2025). This review provides a comprehensive analysis of the fundamental mechanisms of thermoresponsive behaviour, major polymer systems and the most significant applications in tissue engineering. It also outlines cutting-edge innovations such as hybrid nanocomposite hydrogels, stimuli-responsive multifunctional scaffolds and their integration with cell therapies. Finally, the article discusses current limitations—such as mechanical weaknesses, biodegradation challenges and clinical translation barriers—and highlights future research directions needed to fully exploit the potential of thermoresponsive hydrogels in regenerative medicine (Liu et al., 2023; Kim et al., 2024).

Published Paper   E-Certificate

"Applications of Thermoresponsive Hydrogels in Tissue Engineering: A Comprehensive Review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.11, Issue 1, page no.a13-a24, January-2026, Available :https://ijsdr.org/papers/IJSDR2601003.pdf

Volume 11 Issue 1, January-2026

Pages : a13-a24

Paper Reg. ID: IJSDR_306577

Published Paper Id: IJSDR2601003

Downloads: 000218

Research Area: Chemistry All

Country: Gaya Ji, Bihar, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2601003

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2601003

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition