Advancements in Sustained-Release Microsphere Technology for Dual Delivery of Anti-Inflammatory and Gastroprotective Agents
KARUNA NAND MISHRA
, Dr. Atul Kaushik
Keywords: Controlled release, Dual-drug microspheres, NSAID-PPI combination, Solvent evaporation, Gastro-retentive delivery
This study explores the formulation and assessment of microspheres designed for the simultaneous controlled release of an NSAID and a PPI to address pain relief while protecting the stomach lining. Using a solvent evaporation approach with a pH-sensitive polymer, the system achieved prolonged drug release, improved entrapment, and minimal burst effects. Optimized parameters yielded particles with desirable size and morphology, demonstrating over 80% cumulative release in simulated gastric conditions over 8 hours. These findings suggest potential for enhanced therapeutic outcomes in chronic inflammatory conditions, with reduced side effects and better adherence.
"Advancements in Sustained-Release Microsphere Technology for Dual Delivery of Anti-Inflammatory and Gastroprotective Agents", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 8, page no.b718-b719, August-2025, Available :https://ijsdr.org/papers/IJSDR2508186.pdf
Volume 10
Issue 8,
August-2025
Pages : b718-b719
Paper Reg. ID: IJSDR_304738
Published Paper Id: IJSDR2508186
Downloads: 000291
Research Area: Pharmacy All
Country: -, -, India
DOI: https://doi.org/10.56975/ijsdr.v10i8.304738
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
