Design, Synthesis, and Antibacterial Evaluation of Novel Quinoline Derivatives

Vishal Kumar , Prof.(Dr.) Ashutosh Mishra

Quinoline, Synthesis, Characterization, Antimicrobial Activity, Staphylococcus aureus, Structure-Activity Relationship

Quinoline and its derivatives represent an important class of heterocyclic compounds with diverse pharmacological activities, particularly in antimicrobial drug discovery. In the present study, a series of novel quinoline derivatives was designed and synthesized using established synthetic strategies such as the Friedländer condensation and Gould–Jacobs reaction. Quinoline derivatives have garnered significant attention in drug discovery due to their diverse biological activities. Their structural framework serves as a valuable template for the development of antimicrobial and anticancer agents. This study focuses on the synthesis, characterization, and evaluation of quinoline derivatives for their potential activity against Staphylococcus aureus (antibacterial). The primary objective of this research is to synthesize and characterize novel quinoline derivatives and evaluate their biological activity against Staphylococcus aureus for antimicrobial efficacy.A systematic synthetic strategy was employed to prepare a series of quinoline derivatives. The chemical structures of the synthesized compounds were confirmed using Fourier Transform Infrared (FTIR) spectroscopy, Nuclear Magnetic Resonance (NMR) spectroscopy, Mass Spectrometry (MS), and Elemental Analysis. The antimicrobial activity was assessed against Staphylococcus aureus using the agar well diffusion method and the Minimum Inhibitory Concentration (MIC) was determined

Published Paper   E-Certificate

"Design, Synthesis, and Antibacterial Evaluation of Novel Quinoline Derivatives", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 8, page no.b620-b629, August-2025, Available :https://ijsdr.org/papers/IJSDR2508173.pdf

Volume 10 Issue 8, August-2025

Pages : b620-b629

Paper Reg. ID: IJSDR_304649

Published Paper Id: IJSDR2508173

Downloads: 000110

Research Area: Pharmacy All

Country: Balrampur, UP, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2508173

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2508173

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition