Synthesis, characterization and antimycobacterial studies of ethyl 6-(4-chlorobenzoyl)-1,1-dioxo-3,5-diaryl-1,4-thiazinane-2-carboxylates using the green catalyst L-Proline
ethyl 2-[(2-oxo-2-arylethyl)sulfonyl]acetate, L-Proline, thiazine
The four component reaction of ethyl 2-[(2-oxo-2-arylethyl)sulfonyl]acetate, aromatic aldehyde and primary amine/ammonia in a 1:2:1 molar ratio in the presence of L-proline (30 mol %) in ethanol at room temperature for 2-4 hours afforded the [1,4]-thiazine in good yields (75-90 %) . Two [1,4]-thiazines described in the present work, have been previously reported by Reddy et al. albeit in lower yields (72 and 69% respectively) from the reaction of ethyl[(2-oxo-2-arylethyl)sulfonyl]acetate with aromatic aldehyde and ammonium acetate in ethanol, than that obtained in the present study employing (L)-proline (90 and 88% respectively).
"Synthesis, characterization and antimycobacterial studies of ethyl 6-(4-chlorobenzoyl)-1,1-dioxo-3,5-diaryl-1,4-thiazinane-2-carboxylates using the green catalyst L-Proline", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 6, page no.a826-a829, June-2025, Available :https://ijsdr.org/papers/IJSDR2506082.pdf
Volume 10
Issue 6,
June-2025
Pages : a826-a829
Paper Reg. ID: IJSDR_303541
Published Paper Id: IJSDR2506082
Downloads: 000476
Research Area: Chemistry All
Country: Madurai, Tamilnadu, India
DOI: https://doi.org/10.56975/ijsdr.v10i6.303541
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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