Regio and diastereoselective synthesis of dispiroindole-3, 2'-pyrrolidine/pyrrolizines /pyrrolidines-3', 3''-indole derivatives through1,3-dipolar addition and their in vitro activity studies against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant M. tuberculosis

Harikrishnan P.S.

1,3-dipolar cycloaddition, azomethine ylide, pyrrolidine

An efficient synthesis of highly medicinally important dispiroindole-3,2'-pyrrolidine/pyrrolizines /pyrrolidines-3',3''-indole derivativeswas achieved by the 1,3-dipolar cycloaddition of azomethineylide generated insitu by the reaction between isatin and proline/L-Phenyl gycine / Sarcosine to (3-Z)-6-chloro-3-(benzylidene-5-(2-chloroethyl-1,3-dihydro-2H-indol-2-one. These dipolaraphiles upon cycloaddition with azomethineylides affords stereoselectively novel dispiroindole-3,2'-pyrrolidine/pyrrolizines /pyrrolidines-3',3''-indole derivatives in high yield, almost quantitatively. These compounds were characterized by IR, NMR spectroscopy. It is planned to screen these compoundsfor their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant M. tuberculosis (MDR-TB) and Mycobacterium smegmatis (MC2) using agar dilution method.

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"Regio and diastereoselective synthesis of dispiroindole-3, 2'-pyrrolidine/pyrrolizines /pyrrolidines-3', 3''-indole derivatives through1,3-dipolar addition and their in vitro activity studies against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant M. tuberculosis", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 6, page no.a628-a632, June-2025, Available :https://ijsdr.org/papers/IJSDR2506060.pdf

Volume 10 Issue 6, June-2025

Pages : a628-a632

Paper Reg. ID: IJSDR_303516

Published Paper Id: IJSDR2506060

Downloads: 000449

Research Area: Chemistry All

Country: MADURAI, Tamil Nadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2506060

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2506060

DOI: https://doi.org/10.56975/ijsdr.v10i6.303516

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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