Brain Longevity: Extending cognitive life through integrated Neurofeedback Plus therapy and vagal stimulation. Randomized, controlled and multicenter clinical trial

Alina Robu , Alina Diana Nemes

Neurofeedback, HRV, EEG, vagal stimulation, photobiomodulation, neuroplasticity, cognitive longevity, active prevention, healthy seniors.

This randomized, controlled, longitudinal, and multicenter clinical trial investigated the effectiveness of an integrated neurotechnology intervention – Neurofeedback Plus – in supporting cognitive longevity in clinically healthy older adults (60–70 years) by optimizing the functioning of the central and autonomic nervous system. Two hundred participants were randomly assigned to two groups: experimental (n = 100), which received 90 multimodal intervention sessions (EEG neurofeedback, gamma brain photobiomodulation, HRV biofeedback, non-invasive vagal stimulation) conducted in three therapeutic cycles for 12 months; and control group (n = 100), passively monitored. Assessments were performed at four time points (T0, T1, T2, T3), using validated markers: qEEG (global coherence, regional activation), HRV (RMSSD, SDNN, LF/HF), GP-8 (physiological stress) score, and heart-brain coherence biofeedback. Compared to the control group, the experimental group had statistically and clinically significant changes between T0 and T3: RMSSD (+12.8 vs. +2.1), SDNN (+9.2 vs. +1.5), LF/HF (–1.4 vs. –0.2), GP-8 score (-17.6 vs. – 2.8), EEG coherence (+15.2% vs. +3.1%). The interaction effect (Time x Group) was confirmed by the two-way ANOVA (p<0.01) Effect size (Cohen's d > 1.6) and multiple regression analyses indicated belonging to the experimental group as the strongest predictor. Post-hoc statistical power was 1.0 in all cases. The intervention of Neurofeedback Plus produces robust, multisystemic, and lasting effects on brain activity, autonomic regulation, and physiological stress, supporting the strengthening of neuroplasticity and cognitive resilience. The protocol is standardizable, clinically applicable and scalable in the context of public health, providing an innovative preventive solution for maintaining cognitive performance in old age.

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"Brain Longevity: Extending cognitive life through integrated Neurofeedback Plus therapy and vagal stimulation. Randomized, controlled and multicenter clinical trial", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 5, page no.c857-c907, May-2025, Available :https://ijsdr.org/papers/IJSDR2505284.pdf

Volume 10 Issue 5, May-2025

Pages : c857-c907

Paper Reg. ID: IJSDR_303001

Published Paper Id: IJSDR2505284

Downloads: 000448

Research Area: Humanities All

Country: Brașov, Brașov, Romania

Published Paper PDF: https://ijsdr.org/papers/IJSDR2505284

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2505284

DOI: https://doi.org/10.56975/ijsdr.v10i5.303001

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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