STUDY OF CORRELATION OF URINE ALBUMIN CREATININE RATIO WITH DIABETIC RETINOPATHY IN TYPE 2 DIABETES MELLITUS PATIENTS
Sidhartha Yadav
, Kulkarni Shashwat , Abhishek Saklani , Sakshi Mittal , Haritej Anand
Diabetic Retinopathy; UACR; Type 2 Diabetes Mellitus; Chronic Kidney Disease; Biomarker; Microvascular Damage.
Introduction: Diabetes Mellitus (DM) is a chronic metabolic disorder leading to various microvascular complications, including diabetic retinopathy (DR) and diabetic nephropathy (DN). The urine albumin-to-creatinine ratio (UACR) serves as a crucial biomarker for DN, and recent studies suggest a potential correlation between UACR and DR, both related to microvascular damage. Objective: This study aims to explore the correlation between UACR and diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM), assessing the severity of DR and its association with UACR levels and kidney function. Methods: A prospective cross-sectional study was conducted from September 2022 to February 2024 at K.D. Medical College, Mathura. A total of 146 T2DM patients were included, with UACR measured using immunoturbidimetry. DR was assessed using dilated fundus examination and optical coherence tomography (OCT). DR severity was classified based on the Early Treatment Diabetic Retinopathy Study (ETDRS) classification. Data analysis included chi-square tests and receiver operating characteristic (ROC) curve analysis to determine diagnostic accuracy. Results: Among the 146 participants, 41 (28.08%) were diagnosed with diabetic retinopathy (DR). DR patients had significantly higher UACR levels (mean 247.79 mg/g) compared to non-DR patients (mean 57.22 mg/g). The ROC analysis confirmed UACR as a robust diagnostic marker for DR, with an AUC of 97.3%, 90.20% sensitivity, and 100% specificity at a cut-off of 95.73 mg/g. Higher UACR levels were also linked to advanced chronic kidney disease (CKD). Conclusion: Elevated UACR is significantly correlated with the presence and severity of diabetic retinopathy in T2DM patients. UACR can serve as a reliable biomarker for early detection and monitoring of DR and its progression.
"STUDY OF CORRELATION OF URINE ALBUMIN CREATININE RATIO WITH DIABETIC RETINOPATHY IN TYPE 2 DIABETES MELLITUS PATIENTS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 11, page no.20 - 29, November-2024, Available :https://ijsdr.org/papers/IJSDR2411003.pdf
Volume 9
Issue 11,
November-2024
Pages : 20 - 29
Paper Reg. ID: IJSDR_212610
Published Paper Id: IJSDR2411003
Downloads: 000346998
Research Area: Medical Science
Country: Mathura, Uttarpradesh, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
