Formulation And Evaluation Of Ethosomal Gel For Sertaconazole Nitrate (Anti-Fungal Agent)
Pradeep
, Garima Verma , Mr. Prasanjeer Poul
Ethosomes, sertaconazole, Anti-Fungal
The purpose of the present research was develop transdermal drug delivery of sertaconazole nitrate for treatment of cutaneous candidiasis. The main barrier of the skin is located within its uppermost layer, the stratum corneum (SC).Several approaches have been developed to weaken this skin barrier.one of the approaches for increasing the skin penetration of the drug use of vascular system such as, Ethosomes, Ethosomes are phospholipid based elastic nanovesicle, prepared by Hot method, containing soya phosphatidylcholine 3%, and high concentration of ethanol(40%), Ethanol is known as an efficient penetration enhancer and added in a vascular system to prepared elastic nanovesicle. It can interact with the polar head region of the lipid molecule, resulting in the reducing of the melting point of the stratum corneum lipid, thereby increasing lipid fluidity and cell membrane permeability. The optimized ethosomal formulation F5 Show highest EE% (90%), smallest particle size(155.3 ± 1.2), and maximum zeta potential(-42±0.3) was incorporate with Carbopol 934 a gelling agent, to produced ethosomal gel formation. Transmission electron microscopy, differential light scattering, and a vitro release profile, viscosity, spradability, pH determination, Antifungal activity were characterization the optimized formulation no F5. The EE% was found 90 %, show the in vitro skin permeability 67% within 80 min, The gel formulation showed 219.69 gm.cm/sec, it was noticed that ethosomes would improve transdermal flus, prolong release release, and proved an appealing that long term distribution of sertaconazole nitrate, and that the ethosomal delivery method is a successful design for topical drug delivery with improve bioavailability and patient enforcement.
"Formulation And Evaluation Of Ethosomal Gel For Sertaconazole Nitrate (Anti-Fungal Agent)", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 9, page no.397 - 421, September-2024, Available :https://ijsdr.org/papers/IJSDR2409044.pdf
Volume 9
Issue 9,
September-2024
Pages : 397 - 421
Paper Reg. ID: IJSDR_212539
Published Paper Id: IJSDR2409044
Downloads: 000347066
Research Area: Pharmacy
Country: Meerut , Uttar Pradesh , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
