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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: October 2024

Volume 9 | Issue 10

Impact factor: 8.15

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Paper Title: Crispr/cas9 mRNA Therapy gene mutation SRD5A3 in Hepato-cellular carcinoma
Authors Name: Sengthong MOUNPHOUMI , Phonesouda Souphamith , Viengsavanh KHAMMOUNHEUANG , Douangphrachan SATHATHONE , Phetsamay PHOMMASENG
Unique Id: IJSDR2409023
Published In: Volume 9 Issue 9, September-2024
Abstract: A primary hepatocellular carcinoma (HCC, liver cancer for short) is a common malignant tumor that seriously threatens human life and health. It is the sixth most common malignant tumor in humans and ranks third in the global cause of cancer-related deaths. However, the relationship between the expression of SRD5A3 and platinum-based chemotherapy resistance of liver cancer remains to be further explored. Whether the inhibition of centrosome-associated protein SRD5A3 kinase gene by small interfering RNA can inhibit the occurrence and development of hepatocellular carcinoma, the effect of SRD5A3 on the biological behavior of liver cancer cells has not been reported at home and abroad. If the changes in SRD5A3 can be used to guide the diagnosis and treatment of hepatocellular carcinoma and evaluate the prognosis of patients, the related research of SRD5A3 will play a major role in the diagnosis and treatment of hepatocellular carcinoma. These researches use CRISPR/Cas9 (Clustered Regularly Inter Spaced Short Pali
Keywords: CRISPR/Cas9, Liver cancer, proliferation, cycle, invasion.
Cite Article: "Crispr/cas9 mRNA Therapy gene mutation SRD5A3 in Hepato-cellular carcinoma", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 9, page no.218 - 232, September-2024, Available :http://www.ijsdr.org/papers/IJSDR2409023.pdf
Downloads: 00030
Publication Details: Published Paper ID: IJSDR2409023
Registration ID:212447
Published In: Volume 9 Issue 9, September-2024
DOI (Digital Object Identifier): https://doi.org/10.5281/zenodo.13823374
Page No: 218 - 232
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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