FORMULATION AND EVALUATION OF CHEWABLE TABLETS OF LORATADINE PREPARED BY AQUEOUS AND NON-AQUEOUS TECHNIQUES
Nilesh Dayal
, Amreen Khan , Umesh Atneriya , Dr. Dharmendra Solanki
Loratadine, super disintegrants; sodium starch glycollate, crosspovidone and Croscarmellose sodium
Aim of present study was to formulate Loratadine chewable tablets by using aqueous and nonaqueous technique and different super disintegrants and evaluating its characteristics. The chewable tablets of Loratadine were prepared with different level addition of super disintegrants; sodium starch glycollate, crosspovidone and Croscarmellose sodium, for each designed formulations, powder mixed blend of drug and excipients was prepared and evaluated for various parameters. Melting range of Loratadine sample was found to be 135.00 ± 1 O C. pH of Loratadine was found around 7.4 indicating weakly basic in nature. The logP value of Loratadine was found to be in the range of 2.5 to 4 indicating the lipophilic nature of drug. UV absorption spectrum of Loratadine in 0.1 N HCl shows λmax at 247.5 nm. DSC thermogram showed that there was no major difference in onset temperature, end set temperature and peak temperature when compared Chapter-8 Result and Discussion Shri Bherulal Pharmacy Institute, Indore PAGE 57 with pure drug thermogram. All the formulations showed similar thickness. Moreover, friability, hardness, weight variation of all the trials were found to be within the official limits. The assay of drug was performed using UV-Spectrophotometer at wavelength 280nm, using 0.1N HCl as blank solution. All the formulations were within the specification (95-105%) as per USP. The F8 is considered as more optimized formulation. Stability studies of formulation F8 were carried out by placing the samples at temperature 40 O C and different relative humidity conditions 75% RH. From the above observations it was found that there were no significant changes in disintegrate time, release characteristics and physicochemical properties of the tablets used in release study.
"FORMULATION AND EVALUATION OF CHEWABLE TABLETS OF LORATADINE PREPARED BY AQUEOUS AND NON-AQUEOUS TECHNIQUES", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 9, page no.196 - 204, September-2024, Available :https://ijsdr.org/papers/IJSDR2409021.pdf
Volume 9
Issue 9,
September-2024
Pages : 196 - 204
Paper Reg. ID: IJSDR_212429
Published Paper Id: IJSDR2409021
Downloads: 000347126
Research Area: Other
Country: -, -, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
