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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | FORMULATION AND EVALUATION OF CHEWABLE TABLETS OF LORATADINE PREPARED BY AQUEOUS AND NON-AQUEOUS TECHNIQUES |
| Authors Name: | Nilesh Dayal , Amreen Khan , Umesh Atneriya , Dr. Dharmendra Solanki |
| Unique Id: | IJSDR2409021 |
| Published In: | Volume 9 Issue 9, September-2024 |
| Abstract: | Aim of present study was to formulate Loratadine chewable tablets by using aqueous and nonaqueous technique and different super disintegrants and evaluating its characteristics. The chewable tablets of Loratadine were prepared with different level addition of super disintegrants; sodium starch glycollate, crosspovidone and Croscarmellose sodium, for each designed formulations, powder mixed blend of drug and excipients was prepared and evaluated for various parameters. Melting range of Loratadine sample was found to be 135.00 ± 1 O C. pH of Loratadine was found around 7.4 indicating weakly basic in nature. The logP value of Loratadine was found to be in the range of 2.5 to 4 indicating the lipophilic nature of drug. UV absorption spectrum of Loratadine in 0.1 N HCl shows λmax at 247.5 nm. DSC thermogram showed that there was no major difference in onset temperature, end set temperature and peak temperature when compared Chapter-8 Result and Discussion Shri Bherulal Pharmacy Institute, Indore PAGE 57 with pure drug thermogram. All the formulations showed similar thickness. Moreover, friability, hardness, weight variation of all the trials were found to be within the official limits. The assay of drug was performed using UV-Spectrophotometer at wavelength 280nm, using 0.1N HCl as blank solution. All the formulations were within the specification (95-105%) as per USP. The F8 is considered as more optimized formulation. Stability studies of formulation F8 were carried out by placing the samples at temperature 40 O C and different relative humidity conditions 75% RH. From the above observations it was found that there were no significant changes in disintegrate time, release characteristics and physicochemical properties of the tablets used in release study. |
| Keywords: | Loratadine, super disintegrants; sodium starch glycollate, crosspovidone and Croscarmellose sodium |
| Cite Article: | "FORMULATION AND EVALUATION OF CHEWABLE TABLETS OF LORATADINE PREPARED BY AQUEOUS AND NON-AQUEOUS TECHNIQUES", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 9, page no.196 - 204, September-2024, Available :http://www.ijsdr.org/papers/IJSDR2409021.pdf |
| Downloads: | 00030 |
| Publication Details: | Published Paper ID: IJSDR2409021 Registration ID:212429 Published In: Volume 9 Issue 9, September-2024 DOI (Digital Object Identifier): Page No: 196 - 204 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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