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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: November 2024

Volume 9 | Issue 11

Impact factor: 8.15

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Paper Title: DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND FEXOFENADINE IN TABLET DOSAGE FORM.
Authors Name: Ajinkya Zade , Ashpak Tamboli , Abhishek Kamble 3 , Kiran Patil 4
Unique Id: IJSDR2407007
Published In: Volume 9 Issue 7, July-2024
Abstract: A simple, fast and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Montelukast and Fexofenadine. The chromatographic separation was achieved on Phenomenex Kinetex XB-C18 (150 x 4.6 mm, 5µ) column; detection wavelength is 212 nm, mobile phase containing 0.1% Perchloric acid: Acetonitrile (41:59, % v/v) with flow rate of 1.0 mL/min. The retention time of Montelukast and Fexofenadine were 1.69, and 4.61 min respectively. The linearity were found to be in the range of 8-12 µg/mL and 96-144 µg/mL for Montelukast and Fexofenadine with correlation coefficient 1 for Montelukast and 0.999 for Fexofenadine. The proposed methods were validated as per ICH guidelines and successfully applied for the determination of investigated drugs in tablets.
Keywords: Montelukast, Fexofenadine, RP-HPLC, Method development, ICH guidelines
Cite Article: "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND FEXOFENADINE IN TABLET DOSAGE FORM.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 7, page no.57 - 71, July-2024, Available :http://www.ijsdr.org/papers/IJSDR2407007.pdf
Downloads: 000346999
Publication Details: Published Paper ID: IJSDR2407007
Registration ID:211923
Published In: Volume 9 Issue 7, July-2024
DOI (Digital Object Identifier):
Page No: 57 - 71
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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