DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND FEXOFENADINE IN TABLET DOSAGE FORM.
Ajinkya Zade
, Ashpak Tamboli , Abhishek Kamble 3 , Kiran Patil 4
Montelukast, Fexofenadine, RP-HPLC, Method development, ICH guidelines
A simple, fast and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Montelukast and Fexofenadine. The chromatographic separation was achieved on Phenomenex Kinetex XB-C18 (150 x 4.6 mm, 5µ) column; detection wavelength is 212 nm, mobile phase containing 0.1% Perchloric acid: Acetonitrile (41:59, % v/v) with flow rate of 1.0 mL/min. The retention time of Montelukast and Fexofenadine were 1.69, and 4.61 min respectively. The linearity were found to be in the range of 8-12 µg/mL and 96-144 µg/mL for Montelukast and Fexofenadine with correlation coefficient 1 for Montelukast and 0.999 for Fexofenadine. The proposed methods were validated as per ICH guidelines and successfully applied for the determination of investigated drugs in tablets.
"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND FEXOFENADINE IN TABLET DOSAGE FORM.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 7, page no.57 - 71, July-2024, Available :https://ijsdr.org/papers/IJSDR2407007.pdf
Volume 9
Issue 7,
July-2024
Pages : 57 - 71
Paper Reg. ID: IJSDR_211923
Published Paper Id: IJSDR2407007
Downloads: 000347274
Research Area: Pharmacy
Country: Solapur, Maharastra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
