Diabetes Mellitus: A Comprehensive Overview of Sulfonylureas

Bharti Oli , Dr Virender Kaur , Dr Tirath Kumar

Diabetes Mellitus, Insulin-dependent diabetes mellitus, Non insulin-dependent diabetes mellitus, Sulfonylureas, Insulin Resistance.

Diabetes mellitus is a long-term metabolic disease marked by elevated blood sugar levels, a disease that presents serious risks to global health. The entire spectrum of diabetes mellitus is covered in this review article, including its pathogenesis, division into type I (IDDM), type II (NIDDM), and Gestational DM, and characteristics that set each kind apart. After reviewing the fundamentals of diabetes, the emphasis turns to Su’s, a well-known class of antidiabetic medications. In this paper, IR has also been discussed. The review clarifies how molecular alterations affect pharmacological characteristics and therapeutic efficacy by outlining the structural differences among sulfonylureas and their structure-activity relationship. A detailed analysis of the Su's mechanism of action highlights how they block ATP-sensitive potassium channels to stimulate insulin release from pancreatic beta cells. The review also discusses the pharmacokinetics, clinical uses, and possible side effects of Su’s. This article aims to improve knowledge of these antidiabetic medicines and guide their appropriate use in clinical practice by incorporating insights into the classification of diabetes, chemistry, and the complex pharmacological profile of sulfonylureas.

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"Diabetes Mellitus: A Comprehensive Overview of Sulfonylureas", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 6, page no.1301 - 1315, June-2024, Available :https://ijsdr.org/papers/IJSDR2406151.pdf

Volume 9 Issue 6, June-2024

Pages : 1301 - 1315

Paper Reg. ID: IJSDR_211912

Published Paper Id: IJSDR2406151

Downloads: 000347131

Research Area: Chemistry

Country: Nainital, Uttarakhand, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2406151

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2406151

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition