β-Caryophyllene, a review on powerful cannabinoid agent cancer
Gobi Vinoth Kumar KN
, Srinivas K
BCP, Colorectal cancer, FDA, WHO, Phyto cannabinoid, Tumor
CRC is one of the major malignant tumours with a high rate of incidence and mortality. These percentages reflect 9.7% of all cancer diagnoses and 8.9% of all cancer-related deaths in people of both sexes. These findings show that CRC is a serious health issue that requires more research to identify novel anti-cancer medicines and obtain more knowledge on how to improve therapy outcomes. MM.1S and MM.1R were cultured in 6-well plates at a density of 2.5 105 cells/well. BCP (Sigma-Aldrich, St. Louis, MO, USA; purity >80 percent) was applied to the cells for 24 hours at concentrations of 50 and 100 M. Cells were taken after BCP treatment in order to conduct molecular analyses, immunofluorescence, and fluorescein diacetate/propidium iodide (FDA/PI) labelling. Additional cannabinoids' pharmacological targets, such as transient receptor potential vanilloid receptor 1 (TRPV1), orphan G-protein coupled receptor (GPR)55, peroxisome proliferator-activated receptors (PPARs). The PI3K/Akt/mTOR signalling system, which regulates cell proliferation, is abnormally active in a number of malignancies as well as in MM patients, suggesting that a medication that suppresses this route may be useful in the treatment of MM. FM can be treated with a variety of pharmacological and non-pharmacological methods. The main goal of pharmaceutical treatment is to reduce the concentration of pro-nociceptive neurotransmitters. Pregabalin, duloxetine, and milnacipran are the only medications that have received FDA approval for treating FM
"β-Caryophyllene, a review on powerful cannabinoid agent cancer", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 6, page no.1139 - 1145, June-2024, Available :https://ijsdr.org/papers/IJSDR2406131.pdf
Volume 9
Issue 6,
June-2024
Pages : 1139 - 1145
Paper Reg. ID: IJSDR_202898
Published Paper Id: IJSDR2406131
Downloads: 000347196
Research Area: Medical Science
Country: Erode, TAMIL NADU, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
