A NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF EMTRICITABINE IN BULK AND PHARMACEUTICAL FORMULATIONS
Emtricitabine, RP‐HPLC, Method development, Validation
A new, simple, precise, accurate and reproducible RP-HPLC method for Simultaneous estimation of Emtricitabine bulk and pharmaceutical formulations. Separation of Emtricitabine was successfully achieved Dona:YMC PACK PRO 150X4.6mm, 5µm, C18 or equivalenting an isocratic mode utilizing KH2PO4: Methanol(65:35) at a flowrate of 1.0mL/mins and eluate was monitored at 265nm, with a retention time of 3.150 minutes for Emtricitabine respectively. Assay Results 98.82%The specificity of the method shows good correlation between retention times of standard with the sample so, the method specifically determines the analyte in the sample without interference from excipients of tablet dosage forms. The method was extensively validated according to ICH guidelines for Assay.
"A NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF EMTRICITABINE IN BULK AND PHARMACEUTICAL FORMULATIONS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 6, page no.740 - 744, June-2024, Available :https://ijsdr.org/papers/IJSDR2406084.pdf
Volume 9
Issue 6,
June-2024
Pages : 740 - 744
Paper Reg. ID: IJSDR_211767
Published Paper Id: IJSDR2406084
Downloads: 000347112
Research Area: Pharmacy
Country: Sheriguda, TELANGANA, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
