Formulation and Evaluation of Simethicone Nano Suspension

Vipin Rao Sonkar , Pragati Singh , Priyanka Singh , Amar Kumar Mishra , Ashutosh Kumar

Simethicone, anti-flatulent, nanosuspension, in vitro dissolution.

Simethicone, an anti-flatulent medication, is often formulated as a suspension for ease of administration. However, its limited solubility and slow dissolution rate can hinder its therapeutic efficacy. In this study, we aimed to develop and evaluate a simethicone nanosuspension to overcome these challenges and enhance its bioavailability. The nanosuspension was prepared using the precipitation method, with polyvinylpyrrolidone K30 (PVP K30) and sodium lauryl sulfate (SLS) identified as suitable stabilizers through compatibility studies. Various ratios of drug to stabilizer and drug to polymer were investigated, with the optimized batch (NS5) achieving a mean particle size of 258 nm and a zeta potential of -21.8 mV. Stability studies confirmed the formulation's robustness under different conditions. In vitro dissolution studies revealed a remarkable 84 percent increase in drug release within 12 hours compared to a coarse suspension. Particle size reduction was identified as the primary factor contributing to this accelerated dissolution rate. These findings suggest that nano-precipitated simethicone nanosuspensions may offer superior therapeutic benefits over conventional formulations, highlighting their potential for enhanced bioavailability and improved patient outcomes.

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"Formulation and Evaluation of Simethicone Nano Suspension", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 4, page no.289 - 302, April-2024, Available :https://ijsdr.org/papers/IJSDR2404044.pdf

Volume 9 Issue 4, April-2024

Pages : 289 - 302

Paper Reg. ID: IJSDR_210722

Published Paper Id: IJSDR2404044

Downloads: 000347740

Research Area: Life Sciences 

Country: LUCKNOW, UTTAR PRADESH, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2404044

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2404044

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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