Synthesis and Characterization of some Barbituric acid Derivatives
BA, Barbituric acid, Chalcones, epoxide Heterocyclic, six membered ring.
Barbituric acid (BA) derivatives (chalcones) (1 and 2) were prepared from the reaction of -methylcinnamaldehyde or terephthalatedehyde with barbituric acid in the presence of acetic acid through the well-known reaction Knoevenagel, which were converted to chalcone epoxides (3 and 4) by the reaction of chalcones (1 and 2) with hydrogen peroxide. The resulting epoxides (3 and 4) were reacted with hydrazine, urea and thiourea through a Michael addition reaction or a Claisen reaction and then cyclization to give five- and six- heterocyclic compounds that contain in their structure the hydroxyl group (3a-c and 4a-c). These compounds were characterized by TLC, melting point and spectroscopic methods such as FTIR, CHNS, 1H-NMR, 13C- NMR, GC-mass and HRMS.
"Synthesis and Characterization of some Barbituric acid Derivatives", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 2, page no.397 - 417, February-2024, Available :https://ijsdr.org/papers/IJSDR2402059.pdf
Volume 9
Issue 2,
February-2024
Pages : 397 - 417
Paper Reg. ID: IJSDR_210098
Published Paper Id: IJSDR2402059
Downloads: 000347421
Research Area: Chemistry
Country: Mosul, Mosul, Iraq
DOI: https://doi.org/10.5281/zenodo.10674823
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
