DIFFUSION TENSOR IMAGING IN CHILDREN WITH DEVELOPMENTAL DELAY
Dr Anish Chakravarty
, Dr Gautam Muthu
Anisotropy, Children, Corpus callosum, Developmental delay, DTI, MRI
ABSTRACT: Purpose: To determine whether diffusion-tensor magnetic resonance (MR) imaging can depict abnormalities in patients with a diagnosis of developmental delay but structurally normal brain MR imaging results. Materials and methods: Thirty paediatric patients who received a diagnosis of developmental delay underwent brain MR examinations, including diffusion-tensor MR imaging. The MR findings in these patients were compared with those in 30 age-matched neurodevelopmentally healthy children. Mean diffusivity (MD) and anisotropy (FA) were measured bilaterally in regions of interest in anterior and posterior limbs of internal capsule, forceps minor and forceps major, pre and postcentral gyrus, frontal and temporal white matter, and genu, body & Splenium of corpus callosum. By using a one-tailed Student t test in the positive direction for MD and in the negative direction for anisotropy and P <0.05 to indicate a significant difference, the MD and FA values for children with developmental delay were compared with those for children who were neurodevelopmentally healthy. Results: The results of our study revealed that there was a significant reduction in FA values in children with developmental delay, when compared to controls, mapped P values at genu of corpus callosum, body of corpus callosum, splenium of corpus callosum, right anterior limb of internal capsule, left anterior limb of internal capsule, right posterior limb of internal capsule, left posterior limb of internal capsule, right forceps minor, left forceps minor, left forceps major, left precentral gyri, right postcentral gyri, right frontal lobe white matter, left temporal lobe white matter and left temporal lobe white matter (p < 0.005). Also, there was significant increase in MD values in genu of corpus callosum, body of corpus callosum, right anterior limb of internal capsule, left anterior limb of internal capsule, right forceps minor, left forceps major, right postcentral gyri, left postcentral gyri, left frontal lobe white matter, left temporal lobe white matter respectively (p < 0.005). Conclusion: In the children with developmental delay, diffusion-tensor MR imaging depicted decreases in anisotropy and increases in FA in the white matter fiber tracts, which appeared to be normal at conventional MR imaging.
"DIFFUSION TENSOR IMAGING IN CHILDREN WITH DEVELOPMENTAL DELAY", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 12, page no.441 - 450, December-2023, Available :https://ijsdr.org/papers/IJSDR2312060.pdf
Volume 8
Issue 12,
December-2023
Pages : 441 - 450
Paper Reg. ID: IJSDR_209579
Published Paper Id: IJSDR2312060
Downloads: 000347208
Research Area: Medical Science
Country: Bangalore, Karnataka, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
