Formulation and Evaluation of Polymeric Nanoparticle by Emulsion Solvent Evaporation Method
Dr. Shripathy D
, Shreya H Alva , Dr. A R Shabaraya
Drug delivery, Polymeric nanoparticles, Benidipine hydrochloride, Solubility, Emulsion solvent evaporation method
The present work was aimed to formulate and evaluate Polymeric nanoparticles by Emulsion solvent evaporation method. Polymeric nanoparticles are the colloidal drug delivery system with a particle size of 10 – 1000 nm that potentially delivers the therapeutic agent in the systemic circulation in a controlled manner. Benidipine is Biopharmaceutical Classification System (BCS) class-II drug having low solubility and high permeability. Polymeric nanoparticles were prepared using Eudragit S 100 as polymer, poloxamer 188 as surfactant and dichloromethane as organic phase. Drug and polymer compatibility study was analysed by FTIR. The prepared formulation was characterized for melting point, particle size, polydispersity index, entrapment efficiency, zeta potential, surface morphology, in-vitro drug release and kinetic studies.
"Formulation and Evaluation of Polymeric Nanoparticle by Emulsion Solvent Evaporation Method ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 11, page no.469 - 481, November-2023, Available :https://ijsdr.org/papers/IJSDR2311069.pdf
Volume 8
Issue 11,
November-2023
Pages : 469 - 481
Paper Reg. ID: IJSDR_209275
Published Paper Id: IJSDR2311069
Downloads: 000347266
Research Area: Pharmacy
Country: Mangalore, Dakshina Kannada , Karnataka , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
