A NEW ROUTE FOR SCALABLE SYNTHESIS OF 3,5 Bis(hydroxymethyl)phenol AND THEIR DERIVATIVES

Knv. Kiranmayi , Dr. S Shobha Rani

Keywords: 3,5 bis(hydroxymethyl)phenol, Scalable synthesis, Sodium borohydride, 5-hydroxy isophthalic acid, Key organic compound

3,5 bis(hydroxymethyl)phenol belong to the class polyphenols which is widely used for synthesis of complex nuclearity clusters and has clinical relevance in the treatment of allergies. It is a key organic compound widely used in the synthesis of various biologically active products, polymer chemistry and peptide chemistry. Mainly used in synthesis of poly(aryl ether)dendrimers and monodendrons and can also be used as an intermediate for synthesizing ligand and as a reagent for alkali metals. Many literature methods are available for the synthesis of 3,5 bis(hydroxymethyl)phenol using lithium aluminium hydride (LAH) as a reducing agent. But these procedures are not suitable for scaleup due to safety concerns of LAH, tedious workup procedures and difficultly in isolation of product. In this study, a simple and scalable approach for the synthesis of 3,5 bis(hydroxymethyl)phenol was proposed. Methyl ester of 5-hydroxy isophthalic acid was benzylated at the phenol group and reduced with sodium borohydride to obtain diol. The obtained benzylated compound was later debenzylated using Pd/C under H2 conditions for desired product. To study 3,5 bis(hydroxymethyl)phenol further, derivatives was made by methylation, reduction and bromination which yielded 3 derivatives. 3,5 bis(hydroxymethyl)phenol and the derivatives were analyzed using UV Visible spectroscopy, IR spectroscopy and NMR spectroscopy.

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"A NEW ROUTE FOR SCALABLE SYNTHESIS OF 3,5 Bis(hydroxymethyl)phenol AND THEIR DERIVATIVES", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 11, page no.23 - 27, November-2023, Available :https://ijsdr.org/papers/IJSDR2311004.pdf

Volume 8 Issue 11, November-2023

Pages : 23 - 27

Paper Reg. ID: IJSDR_209137

Published Paper Id: IJSDR2311004

Downloads: 000347274

Research Area: Chemistry

Country: Jayalaxmi nagar, TELANGANA, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2311004

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2311004

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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