Formulation and Evaluation of Amphiphilogels of Piroxicam for Enhancement of its Transdermal Drug Delivery
Fabiha Rahish
, Raj Kumar Mishra , Shivani Mishra , Bhanu P. S. Sagar
Amphiphilogels, gelator, hydrophilic, lypophilic, partition co-efficient, penetration enhancer, transdermal flux, thermoreversibility
Piroxicam has very low permeation across skin layers due to its hydrophobicity. Amphiphilogel is a semisolid system serve as a better vehicle for this “Difficult drug”. The preformulation studies were done as a means for identification of drug and gelators. Compatibility studies were done on the basis of FTIR. Solubility and partition co-efficient was measured in different solvents. Tween 80 was proved better over span 80 as a solvent. Amphiphilogels were prepared by weighing span 40 [(3% w/w), (solid gelator)]. Two groups were prepared naming as hydrophilic amphiphilogels and lypophilic amphiphilogels. The samples were found to be pale yellow in color with a minute difference in hydrophilic and lypophilic formulations. On increasing gelator concentration clusters rose in number. All formulations were easily washable and have good spredability. Piroxicam showed greater release from hydrophilic amphiphilogels as compared to lypophilic amphiphilogels. Amongst the hydrophilic amphiphilogels HF4 showed the highest permeation containing ethanol as a co-solvent followed by HF1> HF2 > HF3. Zero order as well as korsmeyer peppas kinetic model both were obeyed by all amphiphilogel formulations. Transdermal flux value were calculated from the slope which suggested that the value of transdermal flux was highest in HF4 contains ethanol as penetration enhancer. All the formulation showed increased transdermal flux then HF0 containing no penetration enhancer. Transdermal flux of hydrophilic amphiphilogels was higher than lypophilic amphiphilogels. All amphiphilogels came to gel state when the temperature was reduced to 40C, indicating their thermoreversibility.
"Formulation and Evaluation of Amphiphilogels of Piroxicam for Enhancement of its Transdermal Drug Delivery", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 10, page no.740 - 757, October-2023, Available :https://ijsdr.org/papers/IJSDR2310115.pdf
Volume 8
Issue 10,
October-2023
Pages : 740 - 757
Paper Reg. ID: IJSDR_208714
Published Paper Id: IJSDR2310115
Downloads: 000347230
Research Area: Other
Country: -, -, -
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
