Formulation Development and Evaluation of Microspheres of Cefpodoxime Proxetil - A Broad Spectrum Cephalosporin with Short Half-life

Shivani Mishra , Raj Kumar Mishra , Fabiha Rahish , Bhanu P. S. Sagar

Bioadhesive, drug release, gastrointestinal tract, melting point determination, microspheres, lipophilic, partition coefficient, polymers, solubility.

In present investigation, to develop mucoadhesive microsphere of cefpodoxime proxetil, it was first identified by characteristics infrared spectra and then it was subjected to melting point determination, partition coefficient determination and solubility analysis. After that the drug was analysed in UV spectrophotometer by constructing standard curve in 0.1 N HCl (pH-1.2). It was found that the drug was confirming all the pharmacopoeial standards with respect to melting point, partition coefficient, solubility, wavelength of maximum absorption (λmax) and the characteristics of IR spectra. Polymer used in formulation of microspheres, may interfere in the estimation of drug. The mp of cefpodoxime proxetil was found to be 1110C. The PC of cefpodoxime proxetil was found to be 5.1 (lipophilic). Formulations FC2 and FC4 follows zero order release kinetics with r2 value of 0.991, 0.998 respectively. From the study it is evident that promising controlled release mucoadhesive microspheres of cefpodoxime proxetil may be developed by solvent evaporation techniques by using polymers for reduced dosing frequency and better patient compliance therapy.

Published Paper   E-Certificate

"Formulation Development and Evaluation of Microspheres of Cefpodoxime Proxetil - A Broad Spectrum Cephalosporin with Short Half-life", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 10, page no.718 - 739, October-2023, Available :https://ijsdr.org/papers/IJSDR2310114.pdf

Volume 8 Issue 10, October-2023

Pages : 718 - 739

Paper Reg. ID: IJSDR_208713

Published Paper Id: IJSDR2310114

Downloads: 000347274

Research Area: Other

Country: -, -, -

Published Paper PDF: https://ijsdr.org/papers/IJSDR2310114

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2310114

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition