Formulation and Evaluation of Hydrogels of Eloxatine (Anti-Neoplastic Drug)

Kuldeep Sharma , Raj Kumar Mishra , Kamal Bani , Bhanu P. S. Sagar

Eloxatine, hydrogels, polymers, colon, cancer, acrylic acid, water imbibitions, scanning electron microscopy, thermogravimetric, gel time.

In PEGA 4000 hydrogels, FTIR analysis of PEG 4000 showed peaks at 3272 (OH), 2882 (Alkyl (-CH2), 1095 (C-O-C), 2988 (C–H) and 1710 Wavelength (cm-1); FTIR analysis of AA showed peaks at 2972 (─CH2─), 1708 (carboxyl group), 1635 (C=O group), 1296 (C-C) and 1173 (C─O); FTIR Analysis of EGDMA confirmed peaks at wavelength (cm-1) 1716 (C=O), 1637 (C=C), 1453 (CH3), 939 and 812 (═CH2). Subsequently, in PEGA 8000 hydrogels, FTIR of PEG 8000 showed peaks at 1094 (C-H),2880 (C–H), 1094 (C–O), 3436 (-OH), 2890 (-CH), specific peaks of EGDMA were found at 1725, 1,453, 953 and 814 and finally EXT confirmed peaks at 1643 carbonyl stretching. Analysis of DSC and TGA clearly indicated more thermal stability than single polymer contents weight loss. SEM analysis proved good attraction forces between polymer and monomer. Finally, more polymeric network = more water diffusion = higher drug Eloxatine (EXT) loading in PEGA 8000 hydrogels (high loading at pH 7.4).

Published Paper   E-Certificate

"Formulation and Evaluation of Hydrogels of Eloxatine (Anti-Neoplastic Drug)", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 9, page no.856 - 869, September-2023, Available :https://ijsdr.org/papers/IJSDR2309123.pdf

Volume 8 Issue 9, September-2023

Pages : 856 - 869

Paper Reg. ID: IJSDR_208666

Published Paper Id: IJSDR2309123

Downloads: 000347172

Research Area: Engineering

Country: -, -, -

Published Paper PDF: https://ijsdr.org/papers/IJSDR2309123

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2309123

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition