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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation of Hydrogels of Eloxatine (Anti-Neoplastic Drug) |
| Authors Name: | Kuldeep Sharma , Raj Kumar Mishra , Kamal Bani , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2309123 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | In PEGA 4000 hydrogels, FTIR analysis of PEG 4000 showed peaks at 3272 (OH), 2882 (Alkyl (-CH2), 1095 (C-O-C), 2988 (C–H) and 1710 Wavelength (cm-1); FTIR analysis of AA showed peaks at 2972 (─CH2─), 1708 (carboxyl group), 1635 (C=O group), 1296 (C-C) and 1173 (C─O); FTIR Analysis of EGDMA confirmed peaks at wavelength (cm-1) 1716 (C=O), 1637 (C=C), 1453 (CH3), 939 and 812 (═CH2). Subsequently, in PEGA 8000 hydrogels, FTIR of PEG 8000 showed peaks at 1094 (C-H),2880 (C–H), 1094 (C–O), 3436 (-OH), 2890 (-CH), specific peaks of EGDMA were found at 1725, 1,453, 953 and 814 and finally EXT confirmed peaks at 1643 carbonyl stretching. Analysis of DSC and TGA clearly indicated more thermal stability than single polymer contents weight loss. SEM analysis proved good attraction forces between polymer and monomer. Finally, more polymeric network = more water diffusion = higher drug Eloxatine (EXT) loading in PEGA 8000 hydrogels (high loading at pH 7.4). |
| Keywords: | Eloxatine, hydrogels, polymers, colon, cancer, acrylic acid, water imbibitions, scanning electron microscopy, thermogravimetric, gel time. |
| Cite Article: | "Formulation and Evaluation of Hydrogels of Eloxatine (Anti-Neoplastic Drug)", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.856 - 869, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309123.pdf |
| Downloads: | 000251446 |
| Publication Details: | Published Paper ID: IJSDR2309123 Registration ID:208666 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 856 - 869 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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