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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: September 2023

Volume 8 | Issue 9

Impact factor: 8.15

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Paper Title: Diclofenac Sodium (NSAID) Proniosomal Formulation for Enhanced Transdermal Delivery
Authors Name: Rajeev Kumar Chahar , Raj Kumar Mishra , Kamal Bani , Bhanu P. S. Sagar
Unique Id: IJSDR2309122
Published In: Volume 8 Issue 9, September-2023
Abstract: The objective of the thesis was to assess proniosomes of DFS to increase its permeation through skin for enhanced transdermal drug delivery in systemic circulation avoiding hepatic first-pass metabolism. Results indicated that all the formulations were found to be smooth and spherical in shape and average particle size (17.52±1.54 to 25.23±1.02; size influenced by agitation). Drug loading efficacy (%) of proniosomes was 90.78±0.96 to 95.92±1.36. Entrapment efficacy was maximum for formulation R4. The in-vitro drug release study was performed in phosphate buffer solution at pH 7.2 and by changing the combination of different types of surfactants the % drug release were found in the range of 85.12±3.82, 80.46±2.54, 83.87±2.92, 79.12±2.62 and 76.25±2.80 for formulations R1, R2, R3, R4, R5 and R6 respectively. Finally, present study conclusively demonstrated that drugs having poor water solubility showed enhanced bioavailability by transdermal route via proniosomes.
Keywords: Drug release, drug loading, entrapment, first pass metabolism, nanotechnology, niosomes, proniosomes, skin, surfactant, transdermal
Cite Article: "Diclofenac Sodium (NSAID) Proniosomal Formulation for Enhanced Transdermal Delivery", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.829 - 855, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309122.pdf
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Publication Details: Published Paper ID: IJSDR2309122
Registration ID:208664
Published In: Volume 8 Issue 9, September-2023
DOI (Digital Object Identifier):
Page No: 829 - 855
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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