Diclofenac Sodium (NSAID) Proniosomal Formulation for Enhanced Transdermal Delivery

Rajeev Kumar Chahar , Raj Kumar Mishra , Kamal Bani , Bhanu P. S. Sagar

Drug release, drug loading, entrapment, first pass metabolism, nanotechnology, niosomes, proniosomes, skin, surfactant, transdermal

The objective of the thesis was to assess proniosomes of DFS to increase its permeation through skin for enhanced transdermal drug delivery in systemic circulation avoiding hepatic first-pass metabolism. Results indicated that all the formulations were found to be smooth and spherical in shape and average particle size (17.52±1.54 to 25.23±1.02; size influenced by agitation). Drug loading efficacy (%) of proniosomes was 90.78±0.96 to 95.92±1.36. Entrapment efficacy was maximum for formulation R4. The in-vitro drug release study was performed in phosphate buffer solution at pH 7.2 and by changing the combination of different types of surfactants the % drug release were found in the range of 85.12±3.82, 80.46±2.54, 83.87±2.92, 79.12±2.62 and 76.25±2.80 for formulations R1, R2, R3, R4, R5 and R6 respectively. Finally, present study conclusively demonstrated that drugs having poor water solubility showed enhanced bioavailability by transdermal route via proniosomes.

Published Paper   E-Certificate

"Diclofenac Sodium (NSAID) Proniosomal Formulation for Enhanced Transdermal Delivery", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 9, page no.829 - 855, September-2023, Available :https://ijsdr.org/papers/IJSDR2309122.pdf

Volume 8 Issue 9, September-2023

Pages : 829 - 855

Paper Reg. ID: IJSDR_208664

Published Paper Id: IJSDR2309122

Downloads: 000347246

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2309122

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2309122

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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