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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Pharmacological Investigations of Ethanolic Roots Extract of Asparagus racemosus Willd |
| Authors Name: | Pratibha Singh , Amrita Singh , Muskan Saxena , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2309120 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | Identity and purity of shatavari roots were established pharmacognostically and herbarium specimen IEC/Pharm/Herb/2022/2224 was deposited in Herbarium Bank. Shatavari roots confirmed phenolic compounds, alkaloids, sterols, flavanoids, steroidal glycosides isoflavones, and tannins. In physicochemical analysis of roots of Asparagus racemosus, roots were free from contamination (low ash values), AIAV 1.6 % (Low acid-insoluble ash values) indicated drug was free from siliceous matters / sand, WSAV 4.42 % (Water soluble ash value) indicated presence of water soluble salts and ASEV (7.94 %), WSEV (8.62%) (solvent extractive values) indicated presence of phyto-constituents and 2.68% (LOD). Asparagus racemosus Willd. EERAR extract induced powerful Rat RBC membrane stabilizing property (45.24% to 86.56% membrane stabilization impact of EERAR). Asparagus racemosus Willd. (shatavari) EERAR (A/B) produced impactful anti-inflammatory activity. The indomethacin induced excellent anti-inflammatory (edema reduced significantly). Asparagus racemosus Willd. EERAR roots extract contains phenolics, sterols and flavonoids possess significant inflammatory effects. Indomethacin and EERAR-B anti-inflammatory effects were very good in comparison of drug vehicle control group (significant at P<0.05 over control). Further, in Cotton pellet-induced granuloma method, Indomethacin (10 mg/kg) inhibition 53.20% ; EERAR-B: (400 mg/kg) inhibition 32.82%; values were significant at p < 0.05). |
| Keywords: | Anti-inflammatory, carageenan, flavonoids, herbal medicines, indomethacin, natural products. paw edema, physicochemical, shatavari, solvent extractive values |
| Cite Article: | "Pharmacological Investigations of Ethanolic Roots Extract of Asparagus racemosus Willd", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.785 - 805, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309120.pdf |
| Downloads: | 000346986 |
| Publication Details: | Published Paper ID: IJSDR2309120 Registration ID:208662 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 785 - 805 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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