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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Anti-hepatotoxic Activities of Combination of Wedelolactone and Berberine against Paracetamol / Atractyloside induced Hepatotoxicity |
| Authors Name: | Muskan Saxena , Amrita Singh , Pratibha Singh , Mohd Zafar , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2309119 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | Pharmacological studies were performed for anti-hepatotoxic activity of BB, WDL and combination of BB with WDl against PCM and ATR induced hepatotoxicity in albino rats. LFTs were assessed with biochemical kits of ALT, AST, AB, T-Prot, AKLP and T-Bil. PCM / ATR induced hepatoxicity increased hepatic biochemical parameters due to hepatic necrosis. Elevated LFTs levels were correlated with necrosis, infiltration, broad infiltration of lymphocytes and kupffer cells, degeneration of hepatocytes (histopathology of PCM and ATR induced dose dependent hepatic lesions or necrosis). Treatment with berberine (100 mg/kg), wedelolactone (100 mg/kg), berberine in combination with wedelolactone (50 mg/kg each) and standard silymarin (140mg/kg) controlled hepato-toxicities (recovered animals to normalcy) with significant alleviation of LFTs. Hepatoprotective properties of BB and WDL (either alone or in combination) significantly reduced lipid peroxidation. Combination showed a remarkable anti-hepatotoxic activity but comparatively lesser anti-hepatotoxic effects then Silymarin. Data was analyzed by ANOVA. Finally, it was found that BB in combination with WDL produced higher anti-hepatotoxic property then individual drug (BB / WDL) but lesser than Silymarin (Standard). Effects were induced by quenching of free radicals, attenuation depleted glutathione and membrane stabilization, inhibition of Phopholipase A2 and their use in combination is recommended for the treatment of DIH / DILI. |
| Keywords: | Antihepatotoxic, atractyloside, berberine, glutathione, micrtomy, peroxidation, necrosis, paracetamol, wedelolactone. |
| Cite Article: | "Anti-hepatotoxic Activities of Combination of Wedelolactone and Berberine against Paracetamol / Atractyloside induced Hepatotoxicity", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.774 - 784, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309119.pdf |
| Downloads: | 000251448 |
| Publication Details: | Published Paper ID: IJSDR2309119 Registration ID:208661 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 774 - 784 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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