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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | IN-SILICO ANTI-INFLAMMATORY ACTIVITY AND QUALITATIVE BIOCHEMICAL ANALYSIS OF MOOLATHUKKU CHOORANAM - A SIDDHA MONOHERBAL FORMULATION |
| Authors Name: | K Govindaraj , N S Prabhusiva , S Sundararajan |
| Unique Id: | IJSDR2309084 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | ABSTRACT: Background :Siddha system of medicine is the indigenous system of medicine practiced in south India especially in Tamilnadu. Moolam (Hemorrhoids) is one of the disease out of 4448 diseases mentioned in Siddha literatures.Yugi Muni has described about Moolam in “Yugi Vaithiya Chinthamani’. Moolathukku Chooranam is a monoherbal drug indicated for Moolam which is mentioned in Gunapadam Mooligai Vakuppu. Aim: The aim of the study is to analyze the in-silico anti inflammatory potential and biochemical analysis of Moolathukku chooranam. Methodology: Binding of phytocomponents with the core amino acids (His70,Asp71, Ser72, Val91,Pro117, Ser119, Thr120, Pro121, Ser122, Thr124, Thr125) of the target by forming hydrogen bond will hinder the function of the inflammatory cytokine IL6 (Interleukin 6) with PDB – 1N26. These amino acid residues are functionally responsible for binding of substrate and inhibitors. Thereby phytocomponents which inhibit the target IL6 (Interleukin 6) may act as a potential therapeutic agent for management of inflammation Result: The study result concludes that Moolathukku chooranam has significant Anti- inflammatory activity. |
| Keywords: | Keywords:Moolam,Hemarrhoids,Moolathukku chooranam,Anti-inflammatory activity. |
| Cite Article: | "IN-SILICO ANTI-INFLAMMATORY ACTIVITY AND QUALITATIVE BIOCHEMICAL ANALYSIS OF MOOLATHUKKU CHOORANAM - A SIDDHA MONOHERBAL FORMULATION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.577 - 580, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309084.pdf |
| Downloads: | 000346991 |
| Publication Details: | Published Paper ID: IJSDR2309084 Registration ID:208544 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 577 - 580 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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