Phytochemical and Pharmacological Studies of Berberine in Combination with Wedelolactone against Rifampicin induced Hepatotoxicity in Albino Wistar Rats

Inayat Ullah Khan , Mohd Zafar , Amrita Singh , Snehil Singh , Bhanu P. S. Sagar

Anti-hepatotoxic, Berberine, Drug-induced Liver injury, High Performance Liquid Chromatography, Instant Preparative Thin Layer Chromatography, Rifampicin, Wedelolactone, Silymarin.

In the present investigation an attempt has been made to perform in-vivo pharmacological investigations of to investigate anti-hepatotoxic effects of berberine in combination with wedelolactone against the known hepatotoxin – rifampicin and to establish the mechanism involved in anti-hepatotoxic activity. Research work was started with isolation of berberine from Beberis aristata (stem bark) and wedelolactone from Eclipta alba (leaves). Their concentration was found to be 1.2% (berberine) and 2.2% (wedelolactone). In pharmacological investigations it was observed that berberine in combination with wedelolactone produced very good anti- hepatotoxic effects through inhibition of Phopholipase A2, quenching of free radicals, attenuation depleted glutathione and membrane stabilization. So the combination of both the drugs possessed higher anti- hepatotoxic property then the individual drug but less than the standard drug Silymarin. So, their use is recommended against other hepatotoxins.

Published Paper   E-Certificate

"Phytochemical and Pharmacological Studies of Berberine in Combination with Wedelolactone against Rifampicin induced Hepatotoxicity in Albino Wistar Rats", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 9, page no.427 - 443, September-2023, Available :https://ijsdr.org/papers/IJSDR2309067.pdf

Volume 8 Issue 9, September-2023

Pages : 427 - 443

Paper Reg. ID: IJSDR_208499

Published Paper Id: IJSDR2309067

Downloads: 000347261

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2309067

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2309067

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition