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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Phytochemical and Pharmacological Studies of Berberine in Combination with Wedelolactone against Rifampicin induced Hepatotoxicity in Albino Wistar Rats |
| Authors Name: | Inayat Ullah Khan , Mohd Zafar , Amrita Singh , Snehil Singh , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2309067 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | In the present investigation an attempt has been made to perform in-vivo pharmacological investigations of to investigate anti-hepatotoxic effects of berberine in combination with wedelolactone against the known hepatotoxin – rifampicin and to establish the mechanism involved in anti-hepatotoxic activity. Research work was started with isolation of berberine from Beberis aristata (stem bark) and wedelolactone from Eclipta alba (leaves). Their concentration was found to be 1.2% (berberine) and 2.2% (wedelolactone). In pharmacological investigations it was observed that berberine in combination with wedelolactone produced very good anti- hepatotoxic effects through inhibition of Phopholipase A2, quenching of free radicals, attenuation depleted glutathione and membrane stabilization. So the combination of both the drugs possessed higher anti- hepatotoxic property then the individual drug but less than the standard drug Silymarin. So, their use is recommended against other hepatotoxins. |
| Keywords: | Anti-hepatotoxic, Berberine, Drug-induced Liver injury, High Performance Liquid Chromatography, Instant Preparative Thin Layer Chromatography, Rifampicin, Wedelolactone, Silymarin. |
| Cite Article: | "Phytochemical and Pharmacological Studies of Berberine in Combination with Wedelolactone against Rifampicin induced Hepatotoxicity in Albino Wistar Rats", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.427 - 443, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309067.pdf |
| Downloads: | 000346980 |
| Publication Details: | Published Paper ID: IJSDR2309067 Registration ID:208499 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 427 - 443 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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