Drug Induced Hepatotoxicity and Hepatoprotective Drugs : A Review
Inayat Ullah Khan
, Mohd Zafar , Amrita Singh , Snehil Singh , Bhanu P. S. Sagar
Liver damage is a term for collection of conditions, diseases and infections that affect the cells, tissues, structures of function of hepatic cells. Hepatotoxicity is disorder which cause of mortality and morbidity due to environmental pollutants; hepatic cancer; alcoholic and intoxicants and other drug therapy. Drug-induced hepatotoxicity (DIH) / Drug-induced Liver injury (DILI) is the most common cause of acute hepatic failure. Drug-induced hepatotoxicity is a severe problem as it affects a huge population around throughout the globe, and it is the most highly cited reason for the failure of drugs. Hepatoprotection is of intense interest and hepato-protective activity of a drug should be based on its ability to reduce the injurious effect or to preserve the architecture and physiological functions of the liver disturbed by a hepatotoxin. Hepatoprotective drugs are those compounds, which mitigate the liver injury caused by hepatotoxic agents. Liver injury treatments are important issue of today’s research domain, because of many allopathic drugs and their toxic influence lead to liver damage. Modern treatment leads to serious adverse effects which eventually hepatic damage with symptoms include indigestion (constipation), fatigue, allergies and chemical sensitivities, jaundice, edema, body weight loss and neurological disorders. Further protective role of herbal drugs is not ignored because, herbal drugs are also acts by multiple pathways and shown full protection in liver disorders so there is a need to study different herbal drugs and their protective mechanism for liver disorders. Isolated active principles / secondary plant metabolites (SPMs) / phyto- pharmaceutical are to be treated like modern drugs and subjected to rigorous testing as required by the regulatory authorities.
"Drug Induced Hepatotoxicity and Hepatoprotective Drugs : A Review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 9, page no.351 - 375, September-2023, Available :https://ijsdr.org/papers/IJSDR2309058.pdf
Volume 8
Issue 9,
September-2023
Pages : 351 - 375
Paper Reg. ID: IJSDR_208500
Published Paper Id: IJSDR2309058
Downloads: 000347036
Research Area: Engineering
Country: -, -, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
