Cisplatin induced Nephrotoxicity and their herbal remedy:A review
Dr.Nihal Naimuddin Shaikh
Cisplatin is a major antineoplastic drug for the treatment of tumors, but it has dose-dependent renal toxicity. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. Recent in vitro and in vivo studies show that numerous herbal remedies such as flavonoids, saponins, alkaloids, polysaccharide, phenylpropanoids, etc. have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage. In this review we describe the molecular mechanisms of cisplatin induced nephrotoxicity and summarize recent findings in the field of herbal remedies that detrmine these mechanisms to protect against cisplatin-induced kidney damage and provide potential strategies for their treatment.
"Cisplatin induced Nephrotoxicity and their herbal remedy:A review ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 9, page no.33 - 37, September-2023, Available :https://ijsdr.org/papers/IJSDR2309006.pdf
Volume 8
Issue 9,
September-2023
Pages : 33 - 37
Paper Reg. ID: IJSDR_208143
Published Paper Id: IJSDR2309006
Downloads: 000347085
Research Area: Medical Science
Country: Pandharpur , Maharashtra , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
