Haemoprotective potential of Picrorhiza kurroa against radiation and mercury induced changes in mice.
Monika Saini
, MANISHA AGARWAL , ARCHANA PUROHIT , ARUNA CHAKRAWARTI , R.K. PUROHIT
radiation .mercury mice,picrorhiza,blood
Ionizing radiation (IR) has a sufficient amount of energy to induce physical symptomatology within minutes of exposure, appearing as the acute radiation syndrome (ARS). The prodromal phase of ARS includes nausea, vomiting, and fatigue. The quality of radiation, dose, and dose-rate are all contributing factors to the differential symptoms of ARS. These prodromal symptoms can be followed by dramatic decrease in peripheral blood cell counts, as hematopoietic cells represent a renewal system consisting of cells with fast division rates that are known to be sensitive to IR. Once in the bloodstream mercury go through catalase and peroxidase-mediated oxidation in the red blood cell and tissue and convert into inorganic mercuric mercury and mercurous mercury, a procedure restriction mercury absorption. High level showing to mercury make changes in the central nervous system, possible outcome in irritability, fatigue, behavioural change, tremors, headache, hearing and cognitive loss, dysarthria, in coordination, hallucination, death, hypertension and change in endothelial function. Picrorhiza kurroa widely used in traditional systems of medicine and have rendered significant radioprotection in both in vitro and in vivo model systems. Plants and their constituents with pharmacological activities that may be relevant to amelioration of radiation-mediated damage, including antiemetic, anti-inflammatory, antioxidant, cell proliferative, wound healing and haemopoietic stimulators are also discussed. In view of above, present study was planned to evaluate the radiation and mecury induced changes in mice and their protection by Picrorhiza kurroa. The animals were exposed to 2.5 Gy of gamma rays with or without mercuric chloride treatment. The more severe changes in the combined treatment group showing synergistic effects. The kutki treated groups showed less prominent changes and early recovery may be due to the protection provided by the drug.
"Haemoprotective potential of Picrorhiza kurroa against radiation and mercury induced changes in mice.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 8, page no.1159 - 1164, August-2023, Available :https://ijsdr.org/papers/IJSDR2308170.pdf
Volume 8
Issue 8,
August-2023
Pages : 1159 - 1164
Paper Reg. ID: IJSDR_208406
Published Paper Id: IJSDR2308170
Downloads: 000347232
Research Area: Life Sciences
Country: BIKANER, RAJASTHAN, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
