Solubility enhancement of lurasidone hydrochloride by solid dispersion technique

G.Rajalakshmi , Aarthi Sankar , Dr.R.Sundhararajan

Keywords: Solid dispersion, Lurasidone hydrochloride Vitamin E TPGS, Cyclodextrin-B, PEG-6000, solubility

Solid dispersion was most widely and successfully applied to improve the solubility, dissolution rates, and consequently the bioavailability of poorly soluble drugs. Lurasidone hydrochloride (LH) is a poorly water-soluble drug. It belongs to BCS class II. It is prescribed as an antipsychotic drug for the treatment of symptoms of mental disorders such as schizophrenia and bipolar disorder. The present study was planned to prepare and evaluate the solid dispersion (SD) of Lurasidone hydrochloride. Solid dispersion of Lurasidone hydrochloride (LH SD) was prepared using Vitamin E TPGS and Polyethylene glycol (PEG) 6000 as a carrier by Fusion method and using Cyclodextrin-B (CD-B) by the solvent evaporation method. The prepared SD was characterized and filled into hard gelatin capsules. The filled hard gelatin capsules were evaluated for weight variation, drug content, and disintegration time, and in-vitro dissolution study. The cumulative amount of drug release of LH: vitamin ETPGS in 1:3 ratio showed 99.31% at the end of 1 hour. Therefore, it can be concluded that the dissolution rate of the poorly soluble drug Lurasidone hydrochloride can be enhanced by formulating it into solid dispersion using water soluble carrier vitamin E TPGS.

Published Paper   E-Certificate

"Solubility enhancement of lurasidone hydrochloride by solid dispersion technique", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 8, page no.669 - 680, August-2023, Available :https://ijsdr.org/papers/IJSDR2308098.pdf

Volume 8 Issue 8, August-2023

Pages : 669 - 680

Paper Reg. ID: IJSDR_208217

Published Paper Id: IJSDR2308098

Downloads: 000347179

Research Area: Pharmacy

Country: Chennai, Tamilnadu, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2308098

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2308098

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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