Stability Indicating High-Performance Liquid Chromatography Method for Determination of Antihistamine Drug Azelastine in Pharmaceutical Formulation

Miss Darshana Niranajan Shende , Mr.Tushar P. Akhare , Dr.Lahu D. Hingane , Prof.Mahesh Mhaske

Azelastine, Statistical Analysis, HPLC, ICH Guidelines etc.

An innovative, sensitive, easy and fast methodology has been developed for estimation of Azelastine. Applied statistical analysis verified that the method is correct, selective, precise and duplicable. The straight forward procedure with high accuracy, wide dimensionality vary and sensitivity imply that the incontestable methodology to be acceptable for routine estimation and internal control assay of pharmaceutical formulations. The detection of the combined dose kind was allotted at 290 nm and rate used was 1.0ml/min. The mobile phase was used as a mixture of acetonitrile and buffer (adjusted to pH scale 3.0 with 5N NaOH) and was pumped up at a relentless rate of 1.5 cc per minute. This analysis study focuses on the event of the superior layer activity methodology mistreatment style of experiment approach for the determination of Azelastine coordination compound alongside forced degradation study. Full factorial style was applied on acid and base elicited degradation and applied mathematics analysis by analysis of variance was performed with interpretation of varied plots. The method was valid by determination of dimensionality, precision, accuracy, specificity and strength in keeping with ICH Guidelines. The target of this analysis was to develop a straight forward, precise, accurate, and stability-indicating high performance liquid chromatography methodology for estimation of Azelastine coordination compound (AZL) in pharmaceutical formulation.

Published Paper   E-Certificate

"Stability Indicating High-Performance Liquid Chromatography Method for Determination of Antihistamine Drug Azelastine in Pharmaceutical Formulation", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 8, page no.117 - 122, August-2023, Available :https://ijsdr.org/papers/IJSDR2308017.pdf

Volume 8 Issue 8, August-2023

Pages : 117 - 122

Paper Reg. ID: IJSDR_208028

Published Paper Id: IJSDR2308017

Downloads: 000347183

Research Area: Pharmacy

Country: BEED, MAHARASHTRA, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2308017

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2308017

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition