DEVELOPMENT OF ABELMASCHUS ESCULENTUS L BASED NANOPARTICLES FOR PERMEABILITY ENHANCEMENT OF RIZATRIPTAN BENZOATE VIA NASOPULMONARY ROUTE.
Amulya Jindal
, Mainuddin , Dhananjay Taumar , Khushi Goel , Deepak Tomar
Rizatriptan benzoate, Abelmaschus esculentus L, Nanoparticles, Permeability enhancement, Nasal delivery
Rizatriptan benzoate (RB), a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist has only 40–50% bioavailability orally presystemic metabolized by the enzyme monoamine oxidase-A (MAO-A). This bioavailability issue can be solved with improved AUC brain ratios through the development of nose-to-brain delivery systems. Nose-to-brain delivery of RB nanoparticles (NP) is investigated to enhance its bioavailability through avoidance of the presystemic first-pass effect. Polymeric NP from Abelmaschus esculentus L (AE) was prepared by crosslinking method. NP possesses size range of 50-300 nm for RB. The pH was found to be 5.99±0.54 results a polysaccharide solution within the physiological range, hence it is non-irritating to the biological mucosa. Previously surface tension and swelling index demonstrated its mucoadhesive uses. The natural polysaccharide derived from AE can be utilized for the fabrication of NP using the emulsification method by using distilled water, drug, castor oil, and Span 80 (5% v/v). The thermal behavior, particle size (nm), shape and surface morphology, drug encapsulation effectiveness, drug loading, and ex-vivo permeation studies of NP were all characterized. Finally, the in-vivo biodistribution of RB in the brain was investigated using the brain homogenization method by adopting the HPLC method to estimate the drug in male Wistar albino rats. Drug-loaded NP DSC thermograms show that all drug molecules have been evenly distributed throughout the polymer matrix. The mean particle size of NP ranges between 256 and 826 nm and increasing the concentration of polymer resultantly increased the particle size of NP. The formulation’s SEM analyses were spherical with variable surface roughness. Ex-vivo permeation studies show a control release profile for RB improved for intranasal delivery. It concludes that Abelmaschus esculentus L polysaccharide and RB can be implemented in the preparation of NP for nose-to-brain delivery.
"DEVELOPMENT OF ABELMASCHUS ESCULENTUS L BASED NANOPARTICLES FOR PERMEABILITY ENHANCEMENT OF RIZATRIPTAN BENZOATE VIA NASOPULMONARY ROUTE.", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 8, page no.81 - 91, August-2023, Available :https://ijsdr.org/papers/IJSDR2308013.pdf
Volume 8
Issue 8,
August-2023
Pages : 81 - 91
Paper Reg. ID: IJSDR_208001
Published Paper Id: IJSDR2308013
Downloads: 000347176
Research Area: Pharmacy
Country: Meerut, Uttar Pradesh, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
