CBNAAT as a tool for revolutionizing the Diagnosis of Tuberculous Meningitis in Adults: Insights from a Tertiary Care Hospital in Northern India
Dr Pratiksha Kamboj
, Dr Yogendra Pratap Mathuria , Dr Deepika Chakraborty , Dr Pratima Gupta , Dr Priyal Anand
Introduction: Tuberculous meningitis (TBM) remains a challenging and potentially fatal form of extrapulmonary tuberculosis. The conventional methods for TBM diagnosis, such as microscopy and culture, have limitations in terms of sensitivity and speed. The Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) offers a rapid and reliable diagnostic approach for Mycobacterium tuberculosis detection and rifampicin resistance. This study aimed to evaluate the diagnostic usefulness of CBNAAT in diagnosing TBM in adults at a tertiary care hospital in Northern India. Methodology: This study was carried out at the Department of Microbiology, AIIMS, Rishikesh from January 2019 to March 2022. A total of 132 patients admitted with suspicion of tuberculous meningitis in our hospital during the study period were included in this study. Cerebrospinal fluid (CSF) samples were collected from patients and subjected to tests for Zeihl-Neelsen (ZN) staining, CBNAAT and culture. Results: CBNAAT identified MTB in 63/128 samples from the patients (49.2%). In relation to composite reference standards, the CBNAAT's sensitivity, specificity, positive predictive value, and negative predictive value are 98.4%, 100%, 100%, and 98.5%, respectively. Among the 63 instances that CBNAAT identified, 7 incidences of rifampicin resistance were additionally identified (11.11%). A strong statistically significant agreement was observed with CBNAAT.
"CBNAAT as a tool for revolutionizing the Diagnosis of Tuberculous Meningitis in Adults: Insights from a Tertiary Care Hospital in Northern India", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 8, page no.68 - 73, August-2023, Available :https://ijsdr.org/papers/IJSDR2308011.pdf
Volume 8
Issue 8,
August-2023
Pages : 68 - 73
Paper Reg. ID: IJSDR_207189
Published Paper Id: IJSDR2308011
Downloads: 000347351
Research Area: Medical Science
Country: Rishikesh, UTTARAKHAND, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
