AMIFAMPRIDINE PHOSPHATE : AN OVERVIEW
Dr.D.NAGAVALLI
, P.NANTHAGOPAL
Amifampridine Phosphate( FIRDAPSE) , Lambert–Eaton myasthenic syndrome(LEMS),Blocking potassium channel efflux, Neuro Muscular Junctions (NMJs).
Amifampridine is used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. It is also used to treat symptoms of Lambert–Eaton myasthenic syndrome Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. LEMS is a rare auto-immune disorder of the neuromuscular junction that is characterized by proximal muscle weakness, depressed tendon reflexes, and posttetanic potentiation in addition to autonomic dysfunction. Amifampridine improves muscle strength and resting compound muscle action potential (CMAP). Amifampridine phosphate is a more stable salt that serves as an active ingredient of EMA-approved Firdapse, which was previously marketed as Zenas. . Amifampridine is the nonimmune treatment options for LEMS. In phase III clinical trials of adult patients with LEMS, treatment of amifampridine significantly improved symptoms of LEMS compared to placebo with good tolerance. Amifampridine is indicated for the symptomatic treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults and pediatric patients.
"AMIFAMPRIDINE PHOSPHATE : AN OVERVIEW", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 6, page no.155 - 165, June-2023, Available :https://ijsdr.org/papers/IJSDR2306027.pdf
Volume 8
Issue 6,
June-2023
Pages : 155 - 165
Paper Reg. ID: IJSDR_207017
Published Paper Id: IJSDR2306027
Downloads: 000347263
Research Area: Pharmacy
Country: Chengalpattu, Tamilnadu, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
