CYTOKINE PROFILE OF TYPE 1 AND TYPE 2 T HELPER-CELLS IN CHILDREN WITH ACUTE IMMUNE THROMBOCYTOPENIA
Dr.Vanita Bhaskar
, Dr.Anita Nangia , Dr.Sunita Sharma , Dr. Jagdish Chandra , Dr.Anju Seth
Acute Immune Thrombocytopenia, Cytokines, Immunomodulatory, ELISA, Interleukin (IL), Interferon gamma (IFNy), Reticuloendothelial system.
Background: Dysfunctional cellular immunity may play an important role in pathophysiology of Immune thrombocytopenia (ITP). Aim: To study pretreatment and posttreatment cytokine profile of Th1 (IL-2, IFNy) and Th2 (IL-4, IL-10) T cells in children with acute Immune thrombocytopenia. Methods and Material: A total of 30 patients of acute ITP will be tested for CBC, Platelet Count, Peripheral Smear examination (P/S), Bone Marrow Aspirate Examination(BMA), Serum Anti-platelet Antibody and Serum Cytokine levels (Th1=IFNγ, IL2 and Th2=IL4, IL10) using ELISA method. To study the sequential changes in serum cytokine levels pre and post treatment with immunomodulatory treatment, platelet count and serum cytokine levels were analysed on the Day 0 i.e pre-treatment and on Day 1, Day 4 and Day 30 post-treatment. PS, BMA and SAPA were performed only on Day 0. Results: Level of Th1 cytokines i.e IFNγ and IL-2 were found to be high and Th2 cytokines i.e IL-4 and IL-10 were low in all the patients with active disease. After immunomodulatory treatment, Th1 level got decreased and Th2 levels increased significantly on Day 1 after treatment which continued on Day 4, 7, 30. Conclusion: Increased Th1 cytokine- IFNy & IL2 and decreased Th2 cytokine – IL4 & IL10 levels in patients with active disease which get normalised by immunomodulatory treatment.
"CYTOKINE PROFILE OF TYPE 1 AND TYPE 2 T HELPER-CELLS IN CHILDREN WITH ACUTE IMMUNE THROMBOCYTOPENIA", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 5, page no.623 - 627, May-2023, Available :https://ijsdr.org/papers/IJSDR2305091.pdf
Volume 8
Issue 5,
May-2023
Pages : 623 - 627
Paper Reg. ID: IJSDR_206141
Published Paper Id: IJSDR2305091
Downloads: 000347215
Research Area: Medical Science
Country: RAIPUR, CHHATTISGARH, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
