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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | CYTOKINE PROFILE OF TYPE 1 AND TYPE 2 T HELPER-CELLS IN CHILDREN WITH ACUTE IMMUNE THROMBOCYTOPENIA |
| Authors Name: | Dr.Vanita Bhaskar , Dr.Anita Nangia , Dr.Sunita Sharma , Dr. Jagdish Chandra , Dr.Anju Seth |
| Unique Id: | IJSDR2305091 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | Background: Dysfunctional cellular immunity may play an important role in pathophysiology of Immune thrombocytopenia (ITP). Aim: To study pretreatment and posttreatment cytokine profile of Th1 (IL-2, IFNy) and Th2 (IL-4, IL-10) T cells in children with acute Immune thrombocytopenia. Methods and Material: A total of 30 patients of acute ITP will be tested for CBC, Platelet Count, Peripheral Smear examination (P/S), Bone Marrow Aspirate Examination(BMA), Serum Anti-platelet Antibody and Serum Cytokine levels (Th1=IFNγ, IL2 and Th2=IL4, IL10) using ELISA method. To study the sequential changes in serum cytokine levels pre and post treatment with immunomodulatory treatment, platelet count and serum cytokine levels were analysed on the Day 0 i.e pre-treatment and on Day 1, Day 4 and Day 30 post-treatment. PS, BMA and SAPA were performed only on Day 0. Results: Level of Th1 cytokines i.e IFNγ and IL-2 were found to be high and Th2 cytokines i.e IL-4 and IL-10 were low in all the patients with active disease. After immunomodulatory treatment, Th1 level got decreased and Th2 levels increased significantly on Day 1 after treatment which continued on Day 4, 7, 30. Conclusion: Increased Th1 cytokine- IFNy & IL2 and decreased Th2 cytokine – IL4 & IL10 levels in patients with active disease which get normalised by immunomodulatory treatment. |
| Keywords: | Acute Immune Thrombocytopenia, Cytokines, Immunomodulatory, ELISA, Interleukin (IL), Interferon gamma (IFNy), Reticuloendothelial system. |
| Cite Article: | "CYTOKINE PROFILE OF TYPE 1 AND TYPE 2 T HELPER-CELLS IN CHILDREN WITH ACUTE IMMUNE THROMBOCYTOPENIA", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.623 - 627, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305091.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2305091 Registration ID:206141 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 623 - 627 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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