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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.15 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Investigating the effectiveness of Benzamide Derivatives as Anti-TB Agents: a Comparative Analysis with Existing Drugs |
| Authors Name: | Abhishikta Chakladar , Chinmay Pandey , Yash Bhandari |
| Unique Id: | IJSDR2305031 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | This research investigates the potential of benzamide derivatives as anti-TB agents. A total of 72 molecules were designed by substituting some Quinazoline derivatives, which have previously shown good anti-tubercular activities. These molecules were then subjected to pharmacokinetic studies using Swiss ADME software. To further evaluate their effectiveness, the designed molecules were docked using Molegro Virtual Docker to study their amino-acid interactions with target proteins. The results showed that some of the designed molecules had promising amino-acid interactions and could potentially be effective anti-TB agents. This study provides valuable insights into the development of new drugs to combat TB. |
| Keywords: | Benzamide derivatives, anti-TB agents, Quinazoline derivatives, pharmacokinetic studies using Swiss ADME software, Molegro Virtual Docker docking, amino-acid interactions with target proteins, 4U0K,4U0J, tuberculosis. |
| Cite Article: | "Investigating the effectiveness of Benzamide Derivatives as Anti-TB Agents: a Comparative Analysis with Existing Drugs", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.206 - 223, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305031.pdf |
| Downloads: | 000222060 |
| Publication Details: | Published Paper ID: IJSDR2305031 Registration ID:205994 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 206 - 223 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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