Self Microemulsifying Drug Delivery System: A Review

Sonal Sunil Salunke , Akshay Sanjay Chikate , K.B.Burade

Self-Microemulsifying drug delivery system, Surfactant, Co-surfactant, Pseudo-ternary phase diagram.

Self-micro emulsifying drug delivery systems are designed for drugs having pre-systemic first-pass effects, high molecular weights, gastric irritability, enzymatic degradation, slow rates of dissolution, and lower bioavailability. Due to the drug's solubilization in lipidic excipients, which skips the dissolving stage, the generated emulsion delivers faster absorption, faster dissolution rates, and excellent bioavailability, making this method ideal for practically all drugs. SMEDDS, or self-micro emulsifying drug delivery systems, are isotropic blends of natural or synthetic oils, solid or liquid surfactants, or alternatively one or more hydrophilic solvents and co-solvents/surfactants. The review covered the mechanism of self-emulsification in detail as well as the construction of a pseudo ternary phase diagram, the formulation of SMEDDS, its solidification techniques, its characterization, the advantages of SMEDDS over emulsion, and the limitations as well as applications of SMEDDS. This review article wil

Published Paper   E-Certificate

"Self Microemulsifying Drug Delivery System: A Review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 4, page no.2430 - 2442, April-2023, Available :https://ijsdr.org/papers/IJSDR2304379.pdf

Volume 8 Issue 4, April-2023

Pages : 2430 - 2442

Paper Reg. ID: IJSDR_205796

Published Paper Id: IJSDR2304379

Downloads: 000347132

Research Area: Pharmacy

Country: Osmanabad, MAHARASHTRA, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2304379

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2304379

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition