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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | METHANOLIC ROOT EXTRACT OF CITRULLUS COLOCYNTHIS AMELIORATE PARKINSON`S DISEASE IN EXPERIMENTAL ANIMALS |
| Authors Name: | Pushpendra Ahirwar , Yashwant Singh , Abhijit Sahana , Pooja Shrivastava |
| Unique Id: | IJSDR2303142 |
| Published In: | Volume 8 Issue 3, March-2023 |
| Abstract: | Parkinson’s disease (PD) is made, and a significant loss of dopaminergic neurons has already occurred. Identifying patients in the period between the presumed onset of dopaminergic cell loss and the appearance of clinical parkinsonism may be of major importance in the development of effective neuroprotective treatment strategies. In an effort to develop a feasible strategy to detect preclinical PD, a combination of olfactory processing tasks, including odor detection, odor identification, and odor discrimination was used to select groups of hyposmic and normosmic individuals from a total of 250 relatives (parents, siblings, or children) of subjects with PD.α-Synuclein (α-syn) aggregation is central to neuropathological changes in Parkinson’s disease. The aggregates spread within the central nervous system according to a very predictable pattern. A prion-like transmission of α-syn aggregates has been recently proposed to explain this propagation pattern. |
| Keywords: | Citrullus Colocynthis Ameliorate, Natural Product, α-Synuclein, Methanolic Root Extract |
| Cite Article: | "METHANOLIC ROOT EXTRACT OF CITRULLUS COLOCYNTHIS AMELIORATE PARKINSON`S DISEASE IN EXPERIMENTAL ANIMALS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.883 - 891, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303142.pdf |
| Downloads: | 000337209 |
| Publication Details: | Published Paper ID: IJSDR2303142 Registration ID:204658 Published In: Volume 8 Issue 3, March-2023 DOI (Digital Object Identifier): Page No: 883 - 891 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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