|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Focused on In-silico, Design , synthesis & evaluation of 8-hydroxyquinoline based nucleus covering prominent target PDE4 as anti-asthmatic agents |
| Authors Name: | Priyanshu Chauhan , Dr.Neha kawathekar , Gaurav Jain |
| Unique Id: | IJSDR2303111 |
| Published In: | Volume 8 Issue 3, March-2023 |
| Abstract: | Starting with 8-hydroxy quinoline, ten (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 derivatives were created via aldol condensation of substituted benzaldehydes with quinoline chalcones. For anti-asthmatic activity, molecular docking studies were performed on PDE 4 enzyme. Docking studies for anti-asthmatic activity show that compounds 2, 5, and 9 have significant binding interactions with the PDE 4 enzyme. According to studies, replacing the electron withdrawing and electron donating substitutions at the phenyl ring has good anti-asthmatic efficacy. Hence, it is concluded that the synthesized compounds have potent analgesic and anti-asthmatic properties. |
| Keywords: | 3262 |
| Cite Article: | "Focused on In-silico, Design , synthesis & evaluation of 8-hydroxyquinoline based nucleus covering prominent target PDE4 as anti-asthmatic agents", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.690 - 695, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303111.pdf |
| Downloads: | 000337215 |
| Publication Details: | Published Paper ID: IJSDR2303111 Registration ID:204509 Published In: Volume 8 Issue 3, March-2023 DOI (Digital Object Identifier): Page No: 690 - 695 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn