Focused on In-silico, Design , synthesis & evaluation of 8-hydroxyquinoline based nucleus covering prominent target PDE4 as anti-asthmatic agents
Priyanshu Chauhan
, Dr.Neha kawathekar , Gaurav Jain
Starting with 8-hydroxy quinoline, ten (E)-1-(8-hydroxyquinolin-7-yl)-3-phenylprop-2-en-1 derivatives were created via aldol condensation of substituted benzaldehydes with quinoline chalcones. For anti-asthmatic activity, molecular docking studies were performed on PDE 4 enzyme. Docking studies for anti-asthmatic activity show that compounds 2, 5, and 9 have significant binding interactions with the PDE 4 enzyme. According to studies, replacing the electron withdrawing and electron donating substitutions at the phenyl ring has good anti-asthmatic efficacy. Hence, it is concluded that the synthesized compounds have potent analgesic and anti-asthmatic properties.
"Focused on In-silico, Design , synthesis & evaluation of 8-hydroxyquinoline based nucleus covering prominent target PDE4 as anti-asthmatic agents", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 3, page no.690 - 695, March-2023, Available :https://ijsdr.org/papers/IJSDR2303111.pdf
Volume 8
Issue 3,
March-2023
Pages : 690 - 695
Paper Reg. ID: IJSDR_204509
Published Paper Id: IJSDR2303111
Downloads: 000347242
Research Area: Pharmacy
Country: indore, madhya pradesh, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
