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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Current developments in bioanalytical sample preparation technniques in pharmacetuicals |
| Authors Name: | Shraddha Dilip Muneshwar , Amol V Sawale , Vaishnavi S Honale , Sohan S Thipe |
| Unique Id: | IJSDR2303105 |
| Published In: | Volume 8 Issue 3, March-2023 |
| Abstract: | Biological samples represent analysis challenges due to the presence of interfering constituents within the sample matrix. contaminants in these complex samples may clog sampling and extraction devices, non specifically interact with analyte, coextract with target compounds and/ or foul instrumentation through adsorption. Adding to the difficuly, the sample matrix often contains only trace levels of analyte that require a form of proconcentration or purification in order to deliver a sufficient quantity of target compound to the analytical instruments. Because of the low preconcentration factors and extensive use of toxic organic solvents, there has been a growing need to displace them with alternative approaches. The bioanalytical sample preparation is step in the bioanalytical process typically consist of an extraction procedure that results in the isolation and enrichment of compoenants (analyte / metabolite) of interest from a biological matrix (e.g., plasma, urine, skin, saliva etc). These feature article highlights a selection of sample preparation techniques and important recent advances that have significant impact in the life sciences and pharmaceutical industry. |
| Keywords: | Bioanalysis, sample preparation, Cloud point extraction, dried blood spot, air-assisted liquid–liquid microextraction, air-assisted dispersive liquid– liquid microextraction |
| Cite Article: | "Current developments in bioanalytical sample preparation technniques in pharmacetuicals", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.649 - 661, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303105.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2303105 Registration ID:204624 Published In: Volume 8 Issue 3, March-2023 DOI (Digital Object Identifier): Page No: 649 - 661 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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