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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | How cancer drugs are discovered and developed |
| Authors Name: | G.M.Mathiazhagan , DR.G.Ariharasivakumar , K.Monica , E.Santhosh kumar , R.Vinoth kumar |
| Unique Id: | IJSDR2303060 |
| Published In: | Volume 8 Issue 3, March-2023 |
| Abstract: | Cancer may be a complex malady and its genesis and progression are extraordinarily complex.The largest downside within the malignant neoplasm drug development is deed of multi drug resistance and relapse. Classical chemo therapeutics directly target the polymer of the cell, whereas the modern anticancer medication involve molecular-targeted medical care reminiscent of targeting the proteins possessing abnormal expression within the cancer cells.Standard ways for the complete demolition of the cancer cells tested ineffective.Targeted therapy was successful in bound malignancies however, the effectiveness has usually been restricted by drug resistance and side effects on traditional tissues and cells.Since previous few years, several promising drug targets are known for the effective treatment of cancer. This review article describes a number of these promising malignant neoplasm targets that embrace kinases, tubulin, cancer stem cells, being antibodies and microtuble targeting agents. In addition, promising drug candidates underneath varied phases of clinical trials also are described. Multi-acting medication that simultaneously target completely different neoplastic cell signal pathways might facilitate the method of effective anti-cancer drug development |
| Keywords: | Anticancer, Various target statergies, Tubulin, Kinases, Cancer stem cell, Monoclonal antibodies. |
| Cite Article: | "How cancer drugs are discovered and developed", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.388 - 395, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303060.pdf |
| Downloads: | 000337209 |
| Publication Details: | Published Paper ID: IJSDR2303060 Registration ID:204404 Published In: Volume 8 Issue 3, March-2023 DOI (Digital Object Identifier): Page No: 388 - 395 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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