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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Comparison of efficacy and safety of single and combinational therapy of sglt-2in in treatment of diabetes mellitus |
| Authors Name: | Dhanush Bellapu , Ramya Sravanthi , Tahera Mubeen , Padmalatha Kantamaneni , Ronald Darwin |
| Unique Id: | IJSDR2303042 |
| Published In: | Volume 8 Issue 3, March-2023 |
| Abstract: | Abstract Diabetes mellitus is a chronic condition which requires firm glycaemic control with the help of medications and life style changes. Sodium glucose co-transporter 2 inhibitors are novel drugs which exhibit immense benefits on diabetic patients. Currently FDA approved three SGLT-2 where the mode of action is directed towards kidney in potentiating glucose excretion and has pleiotropic effects on reducing HbA1c levels, patient body weight, lipid profile to some extent and blood pressure. Their major positive effects are believed to be focused on cardiovascular and renal functions. SGLT-2 inhibitors especially Dapagliflozin was indicated not only in the management of type 2 diabetes mellitus but also approved for type 1 diabetes mellitus thus providing a way to reduce insulin dose. Risk of hypoglycaemia is significantly increased with use of SGLT-2 inhibitors and insulin in type 1 diabetics but there is no risk when used alone. Many clinical trials were performed and few ongoing trials also suggested good efficacy and safety profiles with use of SGLT-2 inhibitors. Although the use of SGLT-2 inhibitors alone known to be efficacious, their use with other anti-diabetic drug classes presented promising effects. However, SGLT-2 inhibitors are also associated with adverse events such as urinary and genital tract infections, diabetic ketoacidosis, fractures, amputation and kidney injury thus requiring special attention to minimise such effects with appropriate diagnosis and management for better patient survival outcomes. Appropriate SGLT-2 inhibitor use with close patient monitoring, considering prior preventive measures and medication adherence are factors that improve quality of life. |
| Keywords: | Keywords: diabetes mellitus, SGLT-2in, hypoglycaemia, adverse events. |
| Cite Article: | "Comparison of efficacy and safety of single and combinational therapy of sglt-2in in treatment of diabetes mellitus", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 3, page no.259 - 262, March-2023, Available :http://www.ijsdr.org/papers/IJSDR2303042.pdf |
| Downloads: | 000337068 |
| Publication Details: | Published Paper ID: IJSDR2303042 Registration ID:204372 Published In: Volume 8 Issue 3, March-2023 DOI (Digital Object Identifier): Page No: 259 - 262 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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