Comparison of efficacy and safety of single and combinational therapy of sglt-2in in treatment of diabetes mellitus

Dhanush Bellapu , Ramya Sravanthi , Tahera Mubeen , Padmalatha Kantamaneni , Ronald Darwin

Keywords: diabetes mellitus, SGLT-2in, hypoglycaemia, adverse events.

Abstract Diabetes mellitus is a chronic condition which requires firm glycaemic control with the help of medications and life style changes. Sodium glucose co-transporter 2 inhibitors are novel drugs which exhibit immense benefits on diabetic patients. Currently FDA approved three SGLT-2 where the mode of action is directed towards kidney in potentiating glucose excretion and has pleiotropic effects on reducing HbA1c levels, patient body weight, lipid profile to some extent and blood pressure. Their major positive effects are believed to be focused on cardiovascular and renal functions. SGLT-2 inhibitors especially Dapagliflozin was indicated not only in the management of type 2 diabetes mellitus but also approved for type 1 diabetes mellitus thus providing a way to reduce insulin dose. Risk of hypoglycaemia is significantly increased with use of SGLT-2 inhibitors and insulin in type 1 diabetics but there is no risk when used alone. Many clinical trials were performed and few ongoing trials also suggested good efficacy and safety profiles with use of SGLT-2 inhibitors. Although the use of SGLT-2 inhibitors alone known to be efficacious, their use with other anti-diabetic drug classes presented promising effects. However, SGLT-2 inhibitors are also associated with adverse events such as urinary and genital tract infections, diabetic ketoacidosis, fractures, amputation and kidney injury thus requiring special attention to minimise such effects with appropriate diagnosis and management for better patient survival outcomes. Appropriate SGLT-2 inhibitor use with close patient monitoring, considering prior preventive measures and medication adherence are factors that improve quality of life.

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"Comparison of efficacy and safety of single and combinational therapy of sglt-2in in treatment of diabetes mellitus", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 3, page no.259 - 262, March-2023, Available :https://ijsdr.org/papers/IJSDR2303042.pdf

Volume 8 Issue 3, March-2023

Pages : 259 - 262

Paper Reg. ID: IJSDR_204372

Published Paper Id: IJSDR2303042

Downloads: 000347417

Research Area: Pharmacy

Country: Krishna, Andhra Pradesh, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2303042

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2303042

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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