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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Method validation for hydroxycitric acid lactone from garcinia indica by hplc methods |
| Authors Name: | Dilip singh , Shobha yadav , Sandeep singh yadav , Shubham pandey |
| Unique Id: | IJSDR2302010 |
| Published In: | Volume 8 Issue 2, February-2023 |
| Abstract: | A simple HPLC (high performance liquid chromatography) method for the validation of HCA in Garcinia indica has been developed. HCA is major acid component was shown to be potent inhibitor of alpha amylase and alpha glucosidase leading to reduction of carbohydrate metabolism, results in weight loss.HCA inhibits ATP–citrate lyase, a key enzyme responsible for promoting fat synthesis. As a result of this inhibition, energy is di-verted for the production of glycogen in liver and muscles, instead of fat synthesis. Since higher glycogen levels signal satiety to the brain, HCA suppresses appetite. As a direct result of ATP–citrate lyase inhibition, malonyl-CoA is not produced, which indirectly helps in burning the fat. The study of the mechanism of action of HCAL would be difficult for the reason that it exists in equilibrium with HCA under aqueous/acidic conditions. HCAL shows better activity in terms of appetite suppression and reduction in weight gain and this may be due to continuous conversion of HCAL into HCA as it gets utilized by the body. HCAL may thus act as a pro- drug. Once HCAL gets converted into HCA it follows the same mechanism of action as HCA in reducing body weight gain and appetite suppression. |
| Keywords: | Garcinia indica; (−)-Hydroxycitric acid; Antiobesity. |
| Cite Article: | "Method validation for hydroxycitric acid lactone from garcinia indica by hplc methods", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 2, page no.52 - 55, February-2023, Available :http://www.ijsdr.org/papers/IJSDR2302010.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2302010 Registration ID:203749 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: 52 - 55 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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